摘要
目的探讨空肠内营养与全胃肠外营养对重症急性胰腺炎患者临床疗效及免疫功能的影响。方法选取2009年2月—2012年2月于我院接受诊断和治疗的重症急性胰腺炎患者72例,采用随机数字表法分为空肠内营养组(EN组)和全胃肠外营养组(TPN组),每组36例。比较两组临床疗效、并发症发生情况及血清IgA、IgG、IgM水平。结果 EN组治愈19例、有效10例、无效7例,TPN组分别为16、12、8例,两组临床疗效比较,差异无统计学意义(u=-0.586,P>0.05)。EN组感染发生率(7/36)低于TPN组(14/36)(χ2=3.294,P<0.05)。EN组治疗7 d后血清IgA、IgG、IgM水平均高于TPN组(P<0.05)。结论空肠内营养与全胃肠外营养对重症急性胰腺炎患者临床疗效的影响无明显差异,相对于全胃肠外营养,空肠内营养有利于降低患者感染发生率,提高患者免疫功能,无肠梗阻者应尽早行空肠内营养。
Objective To discuss the influence of enteral nutrition （EN） and total parenteral nutrition （TPN） on clinical efficacy and immune function of patients with severe acute pancreatitis （SAP）. Methods Seventy - two SAP patients admitted to this hospital from February 2009 to February 2012 were divided randomly into groups EN and TPN, 36 in each. Clin- ical effects, occurrences of complications and levels of serum IgA, IgG, IgM were compared between the two groups. Results In EN group, 19 were cured, 10 had effects, 7 had no effects; In TPN group, 16, 12, 8, respectively. The difference was not significant （ u = - 0. 586, P 〉 0. 05）. Incidence of infection was lower in EN group than （7/36） in TPN group （14/36） （ X2 = 3. 294, P 〈 0. 05）. Serum IgA, IgG, IgM were higher in EN group than in TPN group after 7 days of treatment （ P 〈 0. 05）. Conclusion There is no significant difference in the influence of EN and TPN on the clinical effects of SAP patients. Compared with TPN, EN is favourable to reducing incidence of infection and improves patients＇immune function. SAP patients without intestinal obstruction should undergo EN as soon as possible.
出处
《中国全科医学》
CAS
CSCD
北大核心
2013年第29期3486-3487,共2页
Chinese General Practice
关键词
肠内营养
胃肠外营养
全
胰腺炎
治疗结果
免疫功能
Enteral nutrition
Parenteral nutrition, total
Pancreatitis
Treatment outcome
Immune function
