摘要
目的探讨原发性干燥综合征(pSS)患者周围神经肌电图的特点。方法选取2011年10月—2012年7月在北京大学人民医院风湿免疫科住院或门诊就诊的pSS患者34例,对其运动、感觉神经电位波幅和神经传导速度检查结果进行分析。结果 34例患者中共发现16例(47.1%)肌电图异常,其中7例运动和感觉神经均受累,6例仅运动神经受累,3例仅感觉神经受累。病程≤5年和>5年患者的尺神经复合肌肉动作电位波幅间差异有统计学意义(P<0.05)。确诊时间≤12个月和>12个月患者的尺神经感觉传导速度间差异有统计学意义(P<0.05)。年龄≤60岁和>60岁患者的腓神经复合肌肉动作电位波幅和感觉电位波幅正常率间差异有统计学意义(P=0.009;P=0.019);发病年龄≤60岁和>60岁患者的腓神经复合肌肉动作电位波幅和感觉电位波幅正常率间差异有统计学意义(P=0.048;P=0.000)。结论 pSS病程长的患者神经损害程度严重,早期确诊和治疗对减缓神经损伤可能发挥一定作用,应重点关注尺神经的肌电图改变。高龄发病者和高龄患者要进行肌电图检查,尤其注意腓神经的运动和感觉电位波幅改变。
Objective To investigate the electromyagraphic characteristics of the peripheral nerves in patients with pri- mary Sjogren＇s syndrome （pSS）. Methods A total of 34 pSS patients treated in our hospital from October 2011 to July 2012 were included in our study. The nerve activities of the motor and sensory nerves and the nerves＇ conduction velocities were exam- ined with electromyography （EMG） and analyzed. Results Abnormalities in the electromyograms were found in 16 patients （ 47.1% ）, of which the motor and sensory nerves were both involved in 7 patients, only motor nerve were involved in 6 patients, and only sensory nerve were involved in 3 patients. The amplitude of compound motor action potential （CMAP） of ulnar nerve was significantly lower in patients with more than 5 years disease duration than that in patients with less than 5 years disease dura- tion （ P 〈 0. 05 ）. The sensory conduction velocity of ulnar nerve decreased more in patients for whom the time of the confirmed diagnosis after onset was longer than 12 months, comparing to those with less time of confirmed diagnosis （P 〈 0. 05 ）. Patients who were over 60 years old and patients whose onset age was over 60 years old had significantly lower normal rate of CMAP and sensory potential of peroneal nerve than those younger patients and those with younger onset age （ P 〈 0. 05 ）. Conclusion The early diagnosis and treatment may help to reduce the nerve damage, for the duration of pSS is related to the severity of nerve dam- age. The doctors should pay attention to the changes in the electromyograms of the ulnar nerve. And EMG, especially of the per- oneal nerve, is necessary for pSS patients who are over 60 years old or whose onset age is over 60 years old.
出处
《中国全科医学》
CAS
CSCD
北大核心
2013年第29期3431-3434,共4页
Chinese General Practice
关键词
干燥综合征
周围神经
肌电描记术
尺神经
腓神经
Sjogren＇s syndrome
Peripheral nerves
Electrophysiolagy
Ulnar nerve
Peroneal nerve
