摘要
目的探讨2型糖尿病肾病患者血清腺苷脱氨酶(ADA)和尿微量清蛋白与肌酐比值(ACR)的关系。方法选择2012年8—12月我院收治并确诊的2型糖尿病肾病患者116例,依据血清ADA水平将其分成A组(ADA<18.0 U/L,n=66)和B组(ADA≥18.0 U/L,n=50),选择同期来我院参加体检的健康成人50例设为对照组。比较3组受试者血清ADA水平与尿ACR,分析其关系。结果 A、B组血清ADA水平和尿ACR均高于对照组(P<0.05),且B组血清ADA水平和尿ACR高于A组(P<0.05)。对照组、A组及B组血清ADA水平与尿ACR均呈正相关关系(r=0.560、0.713、0.846,P=0.00、0.00、0.00)。结论 2型糖尿病肾病患者血清ADA水平与尿ACR均较正常人高,且两者存在正相关关系。
Objective To explore the relationship between serum adenylate deaminase （ADA） and microalbnmin to urinary albumin to creatinine ratio （ACR） in type 2 diabetes mellitus （T2DM） nephropathies patients. Methods One hundred and sixteen T2DM nephropathies patients admitted to this hospital from August to December 2012 were divided, based on serum ADA level, into groups A （ ADA 〈 18. 0 U/L, n = 66） , B （ ADA I〉 18.0 U/L, n = 50） , and 50 healthy subjects were en- rolled as control group. The relationship between serum ADA levels and ACR were compared in 3 groups. Results The levels of serum ADA and ACR were higher in groups A, B than in control group （P 〈 0. 05 ）, and higher in group B than in group A （P 〈 0. 05 ）. Levels of ADA were positively correlated with ACR in 3 groups （ r = 0. 560, 0. 713, 0. 846, respectively ; P = 0. 00, 0. 00, 0. 00, respectively）. Conclusion The levels of ADA and ACR are higher averagely in T2DM nephropathies patients than in normal healthy group, and ADA is positively correlated with ACR.
出处
《中国全科医学》
CAS
CSCD
北大核心
2013年第29期3413-3415,共3页
Chinese General Practice
关键词
糖尿病
2型
糖尿病肾病
白蛋白尿
腺苷脱氨酶
肌酐
Diabetes mellitus, type 2
Diabetic nephropathies
Albuminuria
Adenosine deaminase
Creatinine
