摘要
目的:对红花注射液制备工艺进行系统研究。方法:以羟基红花黄色素A、山奈酚、腺苷为对照品,对红花注射液制备工艺中三种成分的含量进行系统考察,并考察冷冻干燥代替高溫处理对三种成分含量的影响。结果:水提醇沉和水沉工艺均使羟基红花黄色素A和山奈酚的含量有一定损失;高温处理对羟基红花黄色素A和山奈酚的含量均有较大损失,而冷冻干燥损失较小;高温处理和冷冻干燥对腺苷含量无影响。结论:红花注射液制备工艺存在严重缺陷和不合理性。冷冻干燥工艺可以较好保存红花注射液中热不稳定活性成分。
Objective： To study the preparation technology of safflower injections. Method： With hydroxysafflor yellow A, kaempferol and adenosine as the standards, the contents of the components in safflower injections with different preparation process were determined by HPLC,and the contents were also determined with freeze-drying process instead of the high temperature treatment. Result ： The contents of hydroxysafflor yellow A and kaempferol were decreased in the process of water extraction and alcohol deposition or water deposition, and those were significantly decreased by high temperature process compared with those by freeze-drying, while the high temperature and freeze-drying process showed no influence on the content of adenosine. Conclusion： The preparation technology of safflower injections is unreasonable, and the active ingredients with heat sensitivity can be preserved by freeze-drying.
出处
《中国药师》
CAS
2013年第10期1544-1547,共4页
China Pharmacist
