摘要
蛋白分子的氧连接糖基化(O-糖基化)修饰是生物体内必不可少的转录后化学修饰之一,其作用方式类似磷酸化,并且两者之间相互作用,共同调节生物大分子的活性。O-糖基化修饰在生物体的转录、翻译、核运输、细胞骨架的形成以及调节细胞器的功能中发挥着重要的作用。通过影响细胞信号的传导,在细胞吞噬、炎性细胞的迁移以及细胞内大分子物质的循环中也起着重要作用。该文主要通过介绍蛋白分子O-糖基化修饰的基础理论以及O-糖基化修饰作用的几个方面,来简要阐述O-糖基化修饰在生物体内发挥的作用。
The O-GlcNAc modification of protein is one of the essential post-translational modifications in the body, which modification mode is similar to the phosphorylation, and they interact with each other and work cooperatively to regulate the activity of biomacromolecules. The O-GIcNAc modification plays an important role in the process of transcription, translation, nucleus transport, cytoskeletal formation and regulating the functions of organelles. Through its effects on the intracellular signal transduction pathways, it is also involved in the processes of phagocytosis, inflammatory cell migration and intracellular macromolecules circulation. In this article, we briefly explained the role of O-GlcNAcylation in the organism mainly through introducing the basic theory of protein O-GlcNAcylation and several aspects of its functions.
出处
《中国细胞生物学学报》
CAS
CSCD
北大核心
2013年第11期1689-1694,共6页
Chinese Journal of Cell Biology
基金
国家自然科学基金(批准号:81041082)
哈尔滨医科大学附属第一医院院基金(批准号:2011BS004)资助的课题~~
