摘要
近年来,生物钟基因及昼夜节律在肿瘤发生、发展及转移中的研究已成为肿瘤研究领域内的热点。生物钟基因普遍存在于生物界,是生物昼夜节律运转的分子基础。其表达紊乱会增加肿瘤的发病率,通过对肿瘤时间节律性及时间生物学的研究,对指导肿瘤的治疗、预后及转归开辟了一条新思路。本文就生物钟基因及肿瘤的时辰治疗研究进展作一综述。
In recent times,much research has been directed toward studying the role of circadian clock genes and circadian rhythms in tumor development,growth and metastasis.Circadian clock genes,widespread in the biosphere,are the molecular basis of biological circadian rhythm.It can accelerate the growth and metastasis of tumor when the gene expression was disturbed.The research to the tumor circadian and chronobiology opened up a new idea for tumor treatment,prognosis and outcome.The aim of this review is to summarize the advance of circadian clock genes and chronnotherapy for tumor.
出处
《现代肿瘤医学》
CAS
2013年第11期2622-2625,共4页
Journal of Modern Oncology
关键词
生物钟基因
肿瘤
时辰化疗
时辰放疗
circadian clock genes
tumor
chronomodulated chemotherapy
chronomodulated radiotherapy
