摘要
目的分析28例节细胞胶质瘤的临床病理特点,为准确诊断节细胞胶质瘤提供依据。方法对28例中枢神经系统节细胞胶质瘤标本进行回顾性分析,应用HE染色、免疫组化进行病理学特点观察。结果中枢神经系统节细胞胶质瘤以颞叶多见(13/23),临床首发症状多为癫(16/28);平均发病年龄28岁;肿瘤细胞呈弥漫分布、排列紊乱、疏密不匀,部分区域成团分布,其中神经元来源的肿瘤细胞与神经节细胞形态相似,呈多形性,核大不规则可见双核,核仁清楚,胞浆丰富突起,胶质瘤成分以WHOⅠ级星形胶质细胞居多(13/28);免疫组化显示,神经节样细胞SYN、CGA、NSE的表达率达100%,NF、S-100均有不同程度的阳性,胶质细胞中GFAP(100%)及S-100(60%)呈阳性表达,P53及Ki-67表达较低,另外所有肿瘤均有CD34阳性表达(100%)。结论节细胞胶质瘤的诊断主要依靠临床资料、病理组织学及免疫组化标记,CD34可能有利于节细胞胶质瘤的诊断与鉴别。
Objective To investigate the clinical and pathological charactedstics of 28 cases of ganglioglioma, and to provide the basis for valubale guidance for the diagnosis of ganglioglioma. Methods Clinical data of 28 cases with central nervous system gangliaglioma were retrospectively analysis, and the pathological features were observated by HE staining, immunohis tochemical staining. Results Ganglioglioma of the central nervous system commom occur in the temporal lobe （13,/23）, cpilep sy （16/28） always was the first clinical symptoms, average age of onset was 28; the tumor cells presented widcspread derange- ment distribution and conglobatin in some place; the tumor cells were similar with ganglion cell, showing multipolar in feature and had large, irregular nucleoli, the nucleoli were clear, some tumor ceil were bi-nicleated; the majority （13/28） of neuroglio cytomas were I grades according to the standard of WH（）. The expression rates of SYN, CGA, and NSE in neurons were all 100 %, and that of NF and S-100 were in different levels ; GFAP （ 100 % ）, （71）34 （ 100% ） and S-100 （ 60% ） were higher ex pressing in glial cells, but p53 and Ki-67 were lower. Conclusion The diagnosis of Gangliaglioma mainly depends on the immunohistochemical markers and clinical data, and CD34 may be a useful mark in the gangliaglioma diagnosis and differential diagnosls.
出处
《中国实用神经疾病杂志》
2013年第19期9-11,共3页
Chinese Journal of Practical Nervous Diseases
