摘要
目的研究大鼠口服落新妇苷固体分散体后的药动学参数。方法采用HPLC测定大鼠口服落新妇苷固体分散体后血浆中的落新妇苷血药浓度。用Kinetica软件计算药动学参数。结果落新妇苷在大鼠体内的药动学过程符合二室模型。AUC0-480 min为(1.98±0.60)mmol·min·L 1。结论将落新妇苷制成固体分散体可以显著提高其生物利用度。
OBJECTIVE To study the pharmacokinetics of astilbin solid dispersion in rat. METHODS HPLC was used to determine the astilbin concentration in the plasma of rats. The pharmacokinetic parameters were calculated with Kinetica software. RESULTS After the rats were orally administrated with astilbin solide dispersions, the pharmacokinetic process of astilbin in rats was found to be consistent with the two-compartment model. The AUC0.48o min was （1.98±0.60）mmol.min.L-1. CONCLUSION The astilbin in solid dispersion can greatly improve its bioavailability in rat.
出处
《中国现代应用药学》
CAS
CSCD
2013年第10期1102-1104,共3页
Chinese Journal of Modern Applied Pharmacy
