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牛蒡子苷元对高糖刺激大鼠系膜细胞转化生长因子β1表达的影响 被引量：1

Effects of arctigenin on TGF-β1 expression by high glucose stimulated rat glomerular mesangial cells
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摘要 目的观察牛蒡子苷元(ARC-G)对高糖刺激大鼠系膜细胞(GMCs)转化生长因子β1(TGF-β1)表达的影响。方法用葡萄糖(30 mmol/L)刺激大鼠GMCs,经ARC-G(30μmol/L、3μmol/L)培养48 h后,采用实时定量PCR方法检测TGF-β1 mRNA的表达。结果葡萄糖刺激可使GMCs TGF-β1 mRNA的表达增加;经ARC-G处理后,TGF-β1 mRNA的表达下降。结论 ARC-G可以通过抑制GMCs TGF-β1的表达,对损伤的GMCs起保护作用。 Objective： To investigate the effects of arctigenin on transforming growth factor-β1 （TGF-β1） expression by high glucose stimulated rat glomerular mesangial cells. Methods： GMCs were incubated with arctigenin （30 μmol/L, 3 μmol/L） for 48 hours, and the expression of TGF-β1 mRNA was measured by real-time PCR method. Results：Arctigenin decreased the expression of TGF-β1 expression by high glucose stimulated rat glomerular mesangial cells. Conclusion： The arctigenin can protect GMCs by reducing the production of TGF-β1.
作者 赵辉 袁莉 贾莉 王卫华 李琳
机构地区 菏泽医学专科学校
出处 《泰山医学院学报》 CAS 2013年第8期611-612,共2页 Journal of Taishan Medical College
关键词 牛蒡子苷元 系膜细胞 转化生长因子Β1 arctigenin mesangial cells transforming growth factor-β1
分类号 R285.5 [医药卫生—中药学]
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参考文献10

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二级参考文献9

共引文献49

同被引文献20

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泰山医学院学报
2013年 第8期

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