摘要
目的观察晚期结直肠肿瘤经内镜5-FU化疗缓释粒子植入术后近期疗效及对免疫功能的影响。方法21例晚期结直肠癌患者在内镜下进行5-FU化疗粒子植入肿瘤体内治疗,观察治疗后1个月内,瘤体变化情况,临床症状缓解情况、T细胞亚群、免疫球蛋白的变化。结果治疗后1个月,肿瘤体积缩小,有效率为90.5%;临床症状明显缓解;CD3+、CD4+、CD4+/CD8+较治疗前明显增多,差异有统计学意义(P<0.01);CD8+较治疗前明显减少,差异有统计学意义(P<0.01)。结论经内镜化疗粒子植入治疗后,由于瘤体缩小,临床症状明显缓解,免疫功能有所改善,近期疗效肯定,远期疗效有待进一步观察。
Objective To observe recent effectiveness and changes of recent immune function of endoscopic implanta- tion of slow-releasing 5-fluorouracil in the treatment of advanced colorectal tumour. Methods 21 cases of patients with ad- vanced colorectal turnout were enrolled. 1 month after endoscopic implantation, the tumour changes, symptoms, T lymphocyte subpopulations and immunoglobulin were observed. Resnlts After operation for 1 month, the turnout volume decreased, the effective rate was 90.5%, the clinical symptoms relieved. CD3 ~ ,CD4 ~ ,CD4 ＋/CDs ~ increased and CDs ＋ decreased obvious- ly compared before treatment, and the differences were statistically significant（P 〈0.01 ）. Condusions Endoscopic implan- tation of slow-releasing 5-fluorouracil can improve symptoms and immune funfion of the patients with colourectal tumour at late stage. The recent effectiveness is reliable , while the forward effectiveness need further observing.
出处
《临床合理用药杂志》
2013年第29期8-9,共2页
Chinese Journal of Clinical Rational Drug Use
基金
2011年河北省科学技术研究与发展计划(第八批)(No:11276180)
关键词
结直肠肿瘤
粒子植入化疗
T细胞亚群
免疫球蛋白
Colourectal tumour
Implantation of slow-releasing 5-fluorouracil
T lymphocyte subpopulatious
Immuno- globulin
