摘要
目的探讨幽门螺杆菌(Hp)感染与肝硬化患者血氨水平及肝功能分级的关系。方法选择118例肝硬化患者为研究对象,其中Hp感染阳性者78例,Hp阴性者40例。记录2组肝性脑病发生率、检测血氨水平,同时给予Hp阳性者Hp根除治疗,比较治疗前后血氨水平的改变。结果 Hp阳性者肝性脑病发生率为60.3%,显著高于Hp阴性者的32.5%(P<0.05);Hp阳性者血氨水平显著高于Hp阴性者(P<0.05);在Child-Pugh A、B及C级患者中,Hp阳性者血氨水平逐渐升高(P<0.05),而在Hp阴性者则未见显著差异(P>0.05);Hp阳性者行Hp根除治疗后,血氨水平显著下降(P<0.05)。结论肝硬化Hp感染者血氨水平显著升高,肝性脑病发生率高。Hp根除治疗可显著降低血氨水平,有利于肝性脑病的防治。
Objective To explore the relationship of Hp with blood ammonia and liver func- tion grade. Methods A total of 118 patients with liver cirrhosis were selected as research subjects, including 78 Hp positive cases and 40 Hp negative cases. The occurrences of hepatic encephalopathy were recorded and the blood ammonia levels were detected. The Hp positive patients received Hp eradication therapy. The changes of blood ammonia level were compared before and after treatment. Results The occurrence of hepatic encephalopathy in Hp positive patients was much higher than that in Hp negative patients（60.3% vs 32.5%, P〈0.05）. With Hp negative patients, blood am- monia level in Hp positive patients greatly increased （P 〈 0.05）. In child - pugh A, B and C grade patients, blood ammonia level gradually increased in Hp positive patients （P 〈 0.05） ; There were no significant differences of blood ammonia among Child - Pugh A, B and C grade patients in Hp negative group （P 〉0.05）. After treatment, blood ammonia level greatly decreased in Hp positive patients （P 〈 0.05）. Conclusion The blood ammonia level and the occurrence of hepatic en- cephalopathy greatly increase in Hp positive patients. Hp eradication therapy can significantly de- crease the blood ammonia level and be benefit for prevention of hepatic encephalopathy.
出处
《实用临床医药杂志》
CAS
2013年第19期117-119,共3页
Journal of Clinical Medicine in Practice
关键词
肝硬化
幽门螺杆菌
血氨
肝功能分级
肝性脑病
liver cirrhosis
helicobacter pylori
blood ammonia
hepatic encephalopathy
