摘要
目的 探讨闭环靶控输注下不同镇静麻醉深度对全麻患者肌松药（本研究采用顺苯阿曲库铵）用量的影响.方法 选取择期行开腹胃肠手术患者32例,ASA分级Ⅰ～Ⅱ,随机分为A组和B组,每组16例.2组均使用闭环靶控输注技术来维持术中全麻镇静深度,A组维持在BIS值45,B组维持在BIS值55.使用相同剂量的诱导药进行全麻诱导插管,术中肌松维持均使用相同条件的肌松闭环注射系统,记录每位患者肌松药使用剂量、围术期的一般情况及术毕复苏情况.结果 2组患者的一般情况比较差异无统计学意义（P＞0.05）;2组患者全麻维持时每分钟平均顺苯阿曲库铵用量比较无显著差异（P=0.461,P＞0.05）;全麻中阿曲库铵维持剂量以mg/（kg·h）计算,B组阿曲库铵使用剂量明显比A组大,差异有统计学意义（P=0.017,P＜0.05）.结论 全身麻醉深度不同对顺苯阿曲库铵的用药量有影响.全身麻醉深度较浅时,即BIS值为55的患者阿曲库铵用量较大.
Objective To investigate the effects of different sedation anesthesia depths on muscle relaxation doses for patients with general anaethesia in closed - loop target controlled infu- sion. Methods Thirty - two ASA I - II patients undergoing gastrointestinal surgery were ran- domly divided into group A （ n = 16） and group B （ n = 16）. Both groups received closed - loop target controlled infusion technology to maintain different depth of sedation anesthesia. The BIS was 45 in group A and 55 in group B. The same doses and types of induction medicine were admin- istered. Closed- loop muscle relaxant injection system was used in intraoperative musele relaxant maintenance. The doses of muscle relaxation of each patients, perioperative conditions, and post- operative recovery were recorded. Results The general conditions of the two groups were not sta- tistically different （P 〉 0.05）. There was no statistically significant difference between the two groups in the cisatracurium doses per minute （P = 0. 461, P 〉0.05）. The doses of cisatracurium per hour per kilogram were compared in two groups, which showed that the doses of group B was bigger than group A, and there was statistically significant difference （P = 0. 017, P 〈 0.05）. Conclusion Different anasthesia depths have different effects on the doses of eisatracurium. In light anaesthesia depth, in which BIS value is 55, the dose of cisatracurium is bigger.
出处
《实用临床医药杂志》
CAS
2013年第19期47-49,共3页
Journal of Clinical Medicine in Practice
关键词
顺苯阿曲库铵
麻醉深度
全身麻醉
闭环
cisatracurium
anaesthesia depth
general anaesthesia
closed - loop
