摘要
目的探讨肿瘤标志物联合检测在肺癌辅助诊断中的应用价值。方法将105例确诊为肺癌的患者作为肺癌组,将同期收治的肺部良性病变患者98例作为良性病变组,再将同期至本院体检且合格的健康人86例作为对照组。分别检测3组对象包括鳞状细胞癌相关抗原(SCC-Ag)、神经元特异性烯醇化酶(NSE)、细胞角质蛋白19片段(CYFRA21-1)、癌胚抗原(CEA)、糖类抗原125(CA125)水平,比较3组血清肿瘤标志物检测结果的差异,以及单独检测和联合检测的敏感度、特异度。结果肺癌组血清SCC-Ag、NSE、CYFRA21-1、CEA及CA125水平均显著高于良性病变组及对照组。CA125对肺癌的灵敏度最高(61.9%),其次为CEA(52.4%),SCC-Ag的灵敏度最低(9.5%)。4种标志物联合检测的灵敏度最高(87.6%);3种标志物联合检测以CA125+CEA+SCC-Ag的灵敏度较高(85.7%);2种标志物联合检测以CA125+CEA最高(77.1%)。单项检测以及联合检测的特异度均在90%以上,但差异不显著。结论联合检测可显著提高肺癌诊断的敏感性,在肺癌辅助诊断中具有一定临床价值。
Objective To explore the application value of joint detection of tumor markers in assisted diagnosis of lung cancer. Methods One hundred and five patients with lung cancer, 98 with benign lung lesions and 86 healthy people in the same period were divided into lung cancer group, benign lesion group and control group, respectively. The levels of squamous cell carcinoma- related antigen （SCC-Ag）, neuron-specific enolase （NSE）, cyto-keratin 21-1 （ CYFRA21-1 ）, car- cinoma embryonic antigen （CEA） and carbohydrate antigen 125 （CA125） in three groups were de- tected respectively. The difference among the detected results of tumor markers, and the sensitivity and specificity of single and joint detection were compared. Results Serum SCC-Ag, NSE, CYFRA21-1, CEA and CA125 levels in lung cancer group were evidently higher than those in other two groups. CA125 （61.9 % ） had the highest sensitivity for detecting the lung cancer, followed by CEA （52.4%） and SCC-Ag （9.5%）. The sensitivity was the highest in the joint detection of four markers （87.6%）, and the sensitivity of CA125 ＋ CEA＋ SCC-Ag and CA125 ＋ CEA was the high- est in the joint detection of three markers （85.7 % ） and two markers （77.1% ）, respectively. The specificity of both single and joint detection was above 90 % with no significant differences. Conclu- sion Joint detection can remarkably improve the sensitivity in diagnosis of lung cancer, and has a certain clinical value in assisted diagnosis of lung cancer.
出处
《实用临床医药杂志》
CAS
2013年第17期32-35,共4页
Journal of Clinical Medicine in Practice
基金
中国高校医学期刊临床专项资金(11321106)
