摘要
目的探讨冠心病患者中医体质类型与ApoE基因多态性的相关性。方法采用基因测序法检测ApoE基因多态性。对227例冠心病患者进行ApoE基因多态性检测,同时对其中医体质类型进行判定统计,运用SPSS统计软件分析冠心病患者中医体质类型与ApoE基因多态性的相关性。结果痰湿质、瘀血质与E3/E4基因呈正相关性,而与E3/E3基因则呈负相关(P<0.05),结论痰湿质和瘀血质这两种特殊体质与冠心病易感基因E3/E4型及冠心病保护基因E3/E3型有密切关系。
OBJECTIVE Analysis the relationship between the distribution of TCM constitution and ApoE gene Polymorphism in Coronary Heart Disease（CHD）. METHODS Use gene sequencing detection to detect the Poly-morphism of ApoE gene and judge Constitutional types of Chinese medicine of 227 CHD patient. RESULTS Blood turbid stasis constitution and Phlegm-dampness constitution have positive relationship with E3/E4 ApoE gene. They also have negative relationship with E3/E3 ApoE gene（P 〈 0. 05 ）. CONCLUSION Blood turbid stasis constitution and Phlegm-dampness constitution have intimate connection with CHD susceptibility E3/FA ApoE gene and CHD protective E3/E3 ApoE gene.
出处
《海峡药学》
2013年第10期103-106,共4页
Strait Pharmaceutical Journal
关键词
冠心病
中医体质
APOE基因多态性
Coronary Heart Disease（CHD）
Constitutional types of Chinese medicine
ApoE gene Polymorphism
