摘要
背景:目前已有研究证明骨髓间充质干细胞移植治疗糖尿病足能够获得良好的效果。目的:评价骨髓间充质干细胞移植治疗糖尿病足溃疡的效果以及血管内皮生长因子的表达情况。方法:应用文献检索的方法获取骨髓间充质干细胞移植治疗糖尿病足及血管内皮生长因子表达的相关研究文献,对符合研究标准的文献进行深入的数据分析,文章选取骨髓间充质干细胞移植治疗糖尿病足的实验研究和临床应用进行分析,实验研究中,建立大鼠糖尿病足溃疡模型,给予骨髓间充质干细胞移植治疗,观察创面溃疡的愈合情况,并分析血管内皮生长因子的表达情况。临床应用研究中,对应用骨髓间充质干细胞移植治疗糖尿病足的患者进行观察随访,观察创面溃疡的愈合情况以及不良反应发生情况。结果与结论:实验研究显示骨髓间充质干细胞移植治疗糖尿病足创面溃疡的愈合快于常规治疗,但是与正常足溃疡愈合相比仍较慢,且移植治疗后血管内皮生长因子的表达升高,但是低于正常足溃疡对照的水平。临床应用研究显示糖尿病足溃疡患者经骨髓间充质干细胞移植治疗后,创面溃疡基本均可完全愈合,且无心、脑血管疾病、肝肾功能损伤以及出凝血时间改变等不良反应发生。
BACKGROUND： Bone marrow mesenchymal stem cell transplantation has been confirmed to have excellenteffect on the treatment of diabetic foot.OBJECTIVE： To assess the therapeutic effect of bone marrow mesenchymal stem cell transplantation on diabetic foot ulcers and the expression of vascular endothelial growth factor. METHODS： Literatures concerning the effect of bone marrow mesenchymal stem cell transplantation on foot diabetic and expression of vascular endothelial stem cells were retrieved. Articles that met the criteria were analyzed in depth. Here, we analyzed the experimental research and clinical application of bone marrow mesenchymal stem cells in the treatment of diabetic foot. In experimental studies, rat models of diabetic foot ulcers were established and subjected to bone marrow mesenchymal stem cell transplantation to observe wound healing of ulcers and analyze the expression of vascular endothelial growth factor. In clinical research, the follow-up was conducted in diabetic foot patients undergoing bone marrow mesenchymal stem cell transplantation to observe the wound healing of ulcers and adverse reactions. RESULTS AND CONCLUSION： Experimental studies have shown that bone marrow mesenchymal stem cell transplantation is better than conventional treatment in the treatment of diabetic foot ulcers, but the healing of diabetic foot ulcers is still slower than that of normal ulcers. After cell transplantation, the expression of vascular endothelial stem cells is elevated but still lower than that in the normal ulcer controls. Clinical studies have shown that for patients with diabetic foot ulcers, the ulcer wound can be healed after bone marrow mesenchymal stemcell transplantation, as well as there are no cardiovascular and cerebrovascular diseases, liver and kidney damage and changes in bleeding and coagulation time.
出处
《中国组织工程研究》
CAS
CSCD
2013年第40期7169-7174,共6页
Chinese Journal of Tissue Engineering Research
