摘要
目的:探讨普萘洛尔与糖皮质激素比较治疗婴幼儿血管瘤的临床疗效。方法:计算机检索Cochrane图书馆、Medline数据库、Wiley数据库、CNKI数据库及万方数据库,以"普萘洛尔"、"糖皮质激素"、"婴幼儿血管瘤"为关键词,检索各自数据库自2008年至2013年7月期间所有普萘洛尔与糖皮质激素比较治疗婴幼儿血管瘤的随机对照试验,评价纳入研究的方法学质量并进行资料提取后,采用RevMan5.2软件进行Meta分析。结果:共纳入10个随机对照试验(RCT),试验组口服普萘洛尔310例,对照组口服糖皮质激素247例,一共包括557例血管瘤患儿。Meta分析结果显示:试验组和对照组治疗有效率差异有统计学意义[OR=4.85,95%CI(3.245,7.26),P<0.00001],试验组优于对照组;试验组和对照组的不良反应发生率差异有统计学意义[OR=0.08,95%CI(0.05,0.14),P<0.00001],试验组低于对照组。结论:本研究结果证明普萘洛尔与糖皮质激素治疗婴幼儿血管瘤相比较,普萘洛尔能明显提高有效率和降低不良反应发生率。
Objective Research on the clinic effectuality propranolol versus corticosteroids in the treatment of infantile hemangiomas.Methods We searched Cochrane,Medline,Wiley,CNKI and Wan Fang Date.All studies published between June 2008,and May 2013.Randomied controlled trials （RCTS） of the effectuality of propranolol versus corticosteroids in the treatment of infantile hemangiomas.The methodological quality of the included studies was evaluated,and date analyses were performed using the Cochrane Collaboration＇s software RevMan 5.2.Results A total of 10 RCTS involving 557 patients with keloid,which the experimental group include 310 patients and they oral propranolol,and the control group include 247 patients and they oral corticosteroids.A descriptive analysis of the results was presented：Compared with the effective rate,the experimental group and the control group were statistically significant difference [OR=4.85,95％CI （3.245,7.26）,P＜0.00001],and the experimental group better than the control group.Compared with the incidence of adverse reaction,the experimental group and the control group were statistically significant difference [OR=0.08,95％CI （0.05,0.14）,P＜0.00001],and the experimental group less than the control group.Conclusion The results showed that oral propranolol in the treatment of infantile hemangiomas are more significant curative effect,and also can reduce the side effect.
出处
《中国美容医学》
CAS
2013年第19期1942-1946,共5页
Chinese Journal of Aesthetic Medicine
