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生长激素型垂体腺瘤的药物治疗现状 被引量：4

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摘要 生长激素型垂体腺瘤分泌生长激素导致血液中生长激素（growthhormone，GH）及胰岛素样生长因子（insulin-like growth factor-1, IGF-1 ）水平升高，儿童时期表现为巨人症；成人时期表现为肢端肥大症。因此，GH腺瘤的治疗目标是降低血中GH及IGF．1的水平，解除肿瘤占位效应，改善患者的症状，从而降低致死率和致残率，其治疗方案包括手术、放射治疗及药物治疗等。其中药物治疗主要针对于手术后复发或者GH及IGF-1水平不能降到正常的患者，也可用于丧失手术时机或者手术治疗前短期应用等。目前常用的药物有生长抑素（somatostatin）类、多巴胺受体激动剂类和GH受体拮抗剂等。本文将从不同药物治疗GH腺瘤的作用进行综述。一。
作者 曹磊 张亚卓
机构地区 首都医科大学北京市神经外科研究所
出处 《中华神经外科杂志》 CSCD 北大核心 2013年第10期1076-1078,共3页 Chinese Journal of Neurosurgery
基金 国家自然科学基金面上项目（81271522）
关键词 生长激素型垂体腺瘤 药物治疗 GH受体拮抗剂 生长抑素类药物 胰岛素样生长因子 多巴胺受体激动剂 IGF-1 手术后复发
分类号 R736.4 [医药卫生—肿瘤]
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参考文献27

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共引文献4

同被引文献29

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引证文献4

二级引证文献7

中华神经外科杂志
2013年 第10期

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