期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

内质网分子伴侣蛋白在压疮局部缺血性损伤中的表达 被引量：2

The expressions of endoplasmic reticulum molecular chaperone proteins in pressure ulcer on the different stage of ischemic injury
暂未订购
导出
摘要 目的:分析内质网分子伴侣蛋白在压疮损伤中的表达,探讨其在压疮损伤中的作用。方法:将40只雄性SD大鼠随机分为5组(n=8),即对照组(Con),实验组分为1 c组、3 c组、6 c组、9 c组。采用HE染色观察受压组织的病理学变化,免疫组化法和Western blot检测受压肌组织中葡萄糖调节蛋白78(GRP78)、同源蛋白(CHOP)的动态变化。结果:光镜下发现,受压肌肉组织呈现逐渐退化的变化;免疫组化结果显示,实验组中GRP78,CHOP蛋白表达均高于对照组;Western blot检测发现,GRP78蛋白3 c组达到峰值(P<0.05),随后下降;CHOP蛋白1 c组表达显著(P<0.05),随后下降,9 c组再次升高(P<0.05)。结论:内质网应激诱导细胞发生损伤可能与压疮局部组织的缺血性损伤有关。
作者 崔飞飞 潘莹莹 张龙 谢浩煌 时洪雪 肖健 姜丽萍
机构地区 温州医学院护理学院
出处 《中国应用生理学杂志》 CAS CSCD 2013年第3期196-198,共3页 Chinese Journal of Applied Physiology
基金 教育厅重点课题资助(Z201122386)
关键词 内质网应激 压疮 深部组织损伤 缺血性损伤 endoplasmic reticulum stress pressure ulcer deep tissue injury ischemic injury
分类号 R632.1 [医药卫生—外科学]
  • 相关文献

参考文献5

  • 1Stekelenburg A, Gawlitta D, Bader D L, et al. Deep Tissue Injury: How Deep is Our Understanding[J]. Arch Phys Med Rehabil, 2008, 89(7): 1410-1413.
  • 2DeGracia D J, Monfie H L. Cerebral ischemia and the un- folded protein reasonse [J]. J Neurochem, 2004, 91(1): 1- 8.
  • 3王艳艳,孙海琴,张纯瑜,涂倩,孙艳,姜丽萍.压疮早期动物模型的制备及评价[J].护理学杂志,2010,25(14):1-5. 被引量：32
  • 4蔡福满,姜丽萍,杨晔琴,陈军,韦泾云.褥疮不完全性缺血再灌注损伤简易模型的建立[J].中国病理生理杂志,2009,25(4):830-832. 被引量：29
  • 5Oyadomari S, Moil M. Roles of CHOP/GADD153 in endo- plasmic reticulum stress [ J ]. Cell Death Differ, 2004, 11 (4) : 381-389.

二级参考文献21

  • 1McCord S,McElvain V,Sachdeva R,et al.Risk factors associated with pressure ulcers in the pediatric intensive care unit[J].J Wound Ostomy Continence Nurs,2004,31(4):179-183.
  • 2Peirce SM,Skalak TC,Rieger JM,et al.Selective A(2A) adenosine receptor activation reduces skin pressure ulcer formation and inflammation[J].Am J Physiol,2001,281(1):H67-H74.
  • 3Sundin BM,Hussein MA,Glasofer S,et al.The role of allopurinol and deferoxamine in preventing pressure ulcers in pigs[J].Plast Reconstr Surg,2000,105(4):1408-1421.
  • 4Wong VK,Stotts NA.Physiology and prevention of heel ulcers:The state of science[J].J Wound Ostomy Continence Nurs,2003,30(4):191-198.
  • 5Tsuji S,Ichioka S,Sekiya N,et al.Analysis of ischemia-reperfusion injury in a microcirculatory model of pressure ulcers[J].Wound Repair Regen,2005,13(2):209-215.
  • 6Salcido R,Fisher S B,Donofrio J C,et al.An animal model and computer-controlled surface pressure delivery system for the production of pressure ulcers[J].J Rehabil Res Dev,1995,32(2):149-161.
  • 7Salcido R,Popescu A,Ahn C.Animal models in pressure ulcer research[J].J Spinal Cord Med,2007,30(2):107-116.
  • 8Kosiak M.Etiology and pathology of ischemic ulcers[J].Arch Phys Med Rehabil,1959,40(2):62-69.
  • 9Nola G T,Vistnes L M.Differential response of skin and muscle in the experimental production of pressure sores[J].Plast Reconstr Surg,1980,66(5):728-733.
  • 10Reid R R,Sull A C,Mogford J E,et al.A novel murine model of cyclical cutaneous ischemia-reperfusion injury[J].J Surg Res,2004,116(1):172-180.

共引文献50

同被引文献21

  • 1Bouten CV,Oomens CW,Baaijens FP,et al.The etiology of pressure ulcers:skin deep or muscle bound?[J].Arch Phys Med Rehabil,2003,84(4):616-619.
  • 2Black J,Baharestani MM,CuddiganJ,et al.National Pressure Ulcer Advisory Panel's updated pressure ulcer staging system[J].Adv Skin Wound Care,2007,20(5):269-274.
  • 3Stratos I,Li Z,Rotter R,et al.Inhibition of caspase mediated apoptosis restores muscle function after crush injury in rat skeletal muscle[J].Apoptosis,2012,17(3):269-277.
  • 4Wu QL,Shen T,Shao LL,et al.Ischemic postconditioning mediates cardioprotection via PI3K/GSK-3beta/betacatenin signaling pathway in ischemic rat myocardium[J].Shock,2012,38(2):165-169.
  • 5National Pressure Ulcer Advisory Panel.Resources:Education and Clinical Resources:NPUAP Pressure Ulcer Stages/Categories[EB/OL].2007.http://www.npuap.org/resources/educational-and-clinical-resources/npuap-pressureulcer-stages Categories/.
  • 6Liu H,Miller E,van de Water B,et al.Endoplasmic reticulum stress proteins block oxidant induced Ca2+ increases and cell death[J].J Biol Chem,1998,273(21):12858-12862.
  • 7Zhang PL,Lun M,Teng J,et al.Preinduced molecular chaperones in the endnoplasmic reticulum protect cardiomyocytes from lethal injury[J].Ann Clin Lab Sci,2004,34(4):449-457.
  • 8FujioY,Nguyen T,Wencker D,et al.Akt promotes survival of cardiomyocytes in vitro and protects against ischemiareperfusion injury in mouse heart[J].Circulation,2000,101(6):660-667.
  • 9Mozaffari MS,Liu JY,Schaffer SW.Effect of pressure overload on cardioprotection via PI3K-Akt:comparison of postconditioning,insulin,and pressure unloading[J].Am J Hypertens,2010,23(6):668-674.
  • 10刘彤,张承宗,李广平.关注心房颤动的抗氧化治疗[J].中华临床医师杂志（电子版）,2012,6(24):7947-7948. 被引量：4

引证文献2

二级引证文献12

中国应用生理学杂志
2013年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部