摘要
目的探讨脑梗死危险因素与血管内皮功能的相关性。方法选取血管性假血友病因子(vWF)与可溶性血管内皮细胞蛋白C受体(sEPCR)作为脑梗死患者血管内皮功能的评价指标。将急性脑梗死患者分为多危险因素脑梗死组、单危险因素脑梗死组,并选取健康对照组,采用ELISA方法检测其血清中vWF与sEPCR含量。组间比较采用独立样本t检验。且分别将vWF、sEPCR作为因变量,高血压、糖尿病和高脂血症作为自变量行多元线性回归分析。结果多危险因素脑梗死组血浆中vWF与sEPCR含量显著高于单危险因素脑梗死组(P<0.001)。高血压、糖尿病和高脂血等脑梗死危险因素均与vWF和sEPCR存在线性回归关系。结论脑梗死危险因素越多,则血管内皮功能损伤可能越严重。
Objective Explore the relevance of the risk factors for cerebral infarction and vascular endothelial function. Methods Selected vWF and sEPCR as the evaluation index which evaluated endothelial function in patients with cerebral infarction. Divided the patients with acute cerebral infarction into multiple risk factors group , single risk factor group and control group, detected the plasma vWF and sEPCR levels by ELISA. Groups were compared using independent samples t test. And using multiple linear regression analysis, that regarding vWF, sEPCR as the dependent variable, and hypertension, diabetes, hyperlipidemia as independent variables. Results The plasma vWF and sEPCR levels in multiple risk factors group were significantly higher than that in single risk factor group. Risk factors for cerebral infarction such as hypertension, diabetes, hyperlipidemia were related to vWF and sEPCR linear regression. Conclusion The more risk factors for cerebral infarction, the severer vascular endothelial dysfunction are.
出处
《脑与神经疾病杂志》
2013年第3期196-198,共3页
Journal of Brain and Nervous Diseases
基金
湖北省卫生厅科研基金项目(JX5B41)
