摘要
亲环素A(cyclophilin A,CypA)是亲环素家族中发现最早、含量最丰富、研究最深入的一员,是细胞内免疫抑制剂环孢素A(cyclosporin A,CsA)的主要受体。其具有肽基脯氨酰顺反异构酶(peptidyl-prolyl cistrans isomeras,PPIase)的活性和分子伴侣功能,能辅助细胞内蛋白质的正确折叠,参与免疫抑制,介导炎性反应和参与氧化应激应答等多种生物学功能。近期的研究发现,CypA在多种恶性肿瘤中高表达,具有促进癌细胞增殖、抑制细胞凋亡、介导侵袭转移等作用,未来可能成为某些恶性肿瘤诊断和治疗的新靶点。
CypA （cyclophilin A）, the main intracellular receptor of immunosuppressant CsA （cyclosporin A）, is the first discovered and most abundant one in cyclophilin family and has been studied in-depth. CypA has PPlase （peptidyl-prolyl cis-trans isomerase） activity and molecular chaperone functions which enable it playing a role in correct protein folding. CypA also involves in a variety of biological functions such as immune suppression, inflammatory response, and oxidative stress response. Recent studies have found that CypA was overexpressed in many malignant tumors, and it can promote the proliferation of tumor cells, inhibit apoptosis, and mediate tumor invasion and metastasis, it may become a new diagnostic and therapeutic target of some malignant tumors in future.
出处
《肿瘤》
CAS
CSCD
北大核心
2013年第10期928-934,共7页
Tumor
基金
国家自然科学基金资助项目(编号:81071650,30973503,81050007)
高等学校博士学科点专项科研基金资助项目(编号:20122104110028)
辽宁省高等学校攀登学者计划资助项目(编号:2009-2012)
辽宁省科学技术计划资助项目(编号:2011404013-3)
