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寄生性蠕虫组织蛋白酶F研究进展 被引量：1

Research Progress on Cathepsin F of Parasitic Helminths
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摘要 组织蛋白酶F(cathepsin F)是半胱氨酸蛋白酶家族木瓜蛋白酶亚家族的重要成员。寄生性蠕虫组织蛋白酶F可水解半胱氨酸蛋白酶特异性底物,降解血红蛋白等宿主蛋白作为营养物质,参与虫体入侵,且具有免疫反应性,可作为寄生虫病免疫诊断、疫苗研制和抗寄生虫药物筛选的潜在靶点,对寄生虫病防治具有重要意义。本文综述了组织蛋白酶F的结构特征、作用机制及寄生性蠕虫组织蛋白酶F的研究进展。 Cathepsin F is an important member of papain-hke subfamily in eysteine protease family. Cathepsin F of helminth parasites can hydrolyze the specific substrate, degrade host protein such as hemoglobin for nutrition, and be involved in invasion into host tissue. Therefore, cathepsin F serves as a potential target for parasitic disease immunodiagnosis, vaccine design and anti-parasite drug screening. This article reviews the structural characteristics and mechanisms of cathepsin F, and research advances on cathepsin F of parasitic helminths.
作者 曲自刚 付宝权
机构地区 中国农业科学院兰州兽医研究所.家畜疫病病原生物学国家重点实验室.农业部兽医公共卫生重点开放实验室.甘肃省动物寄生虫病重点实验室.兰州
出处 《中国寄生虫学与寄生虫病杂志》 CAS CSCD 北大核心 2013年第5期406-409,共4页 Chinese Journal of Parasitology and Parasitic Diseases
基金 国家自然科学基金(No.31272555) 甘肃省创新研究群体计划项目(No.1210RJIA006)~~
关键词 寄生性蠕虫 组织蛋白酶F 酶活性 免疫反应性 Parasitic helminth Cathepain F Enzymatic activity Immunoreactivity
分类号 R383 [医药卫生—医学寄生虫学]
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参考文献43

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二级参考文献86

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中国寄生虫学与寄生虫病杂志
2013年 第5期

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