摘要
目的评价中性粒细胞CD64对新生儿败血症的诊断价值。方法检索Pubmed上截止2013年3月以前发表的关于中性粒细胞CD64诊断新生儿败血症的英文文献。以QUADAS工具对文献进行评价,通过随机效应模型分析其总体诊断敏感性、特异性、阳/阴性预测值和诊断优势比。以sROC曲线法分析其总体诊断价值。结果 11项研究最终进入了本次Meta分析。中性粒细胞CD64诊断新生儿败血症的总体敏感性为75%（95%CI：72%~78%）;特异性为77%（95%CI：75%~78%）;阳性似然比为4.62（95%CI：2.95~6.17）;阴性似然比为0.30（95%CI：0.20~0.44）;诊断优势比（DOR）为15.68（95%CI：8.64~28.44）;sROC曲线下面积为0.87,Q值为0.80。已有的研究之间存在较大的异质性。结论中性粒细胞CD64对新生儿败血症具有相对较高的诊断准确性。
Objective To evaluate the diagnostic performance of neutrophil CD64 for neonatal sepsis.Methods English-language studies published in Pubmed before March 2013,which focused on the diagnostic efficiency of neutrophil CD64 for neonatal sepsis,were retrieved.The quality of included studies was evaluated by QUADAS tools.The diagnostic sensitivity,specificity,negative/positive likelihood ratios and diagnostic odds ratio（DOR）were pooled by random-effects models.The overall diagnostic performance was estimated by summary receiver operating characteristic（sROC）curves approaches.Results Eleven studies were included in present meta-analysis.The summary estimates for neutrophil CD64 in the diagnosis of neonatal sepsis were as follows：sensitivity,75% （95%CI：72%-78%）;specificity,77% （95% CI,75%-78%）;positive likelihood ratio,4.62（95% CI,2.95-6.17）;negative likelihood ratio,0.30 （95%CI,0.20-0.44）;and DOR,15.68 （95%CI,8.64-28.44）.The area under curve（AUC）for neutrophil CD64 was 0.87 with Q value of 0.80.Significant heterogeneity was observed among included studies.Conclusion Neutrophil CD64 has high diagnostic accuracy for neonatal sepsis.
出处
《国际检验医学杂志》
CAS
2013年第20期2673-2674,2677,共3页
International Journal of Laboratory Medicine
