摘要
目的探讨血清癌胚抗原(CEA)和糖链抗原(CA)19-9联合检测在Ⅳ期胃癌腹膜转移患者的诊断、鉴别中的作用。方法采用酶联免疫吸附法和化学发光免疫分析法对胃癌腹膜转移患者、无腹膜转移胃癌患者和正常人群进行血清CEA、CA19-9检测,分析两者联合检测在诊断和鉴别Ⅳ期胃癌腹膜转移中的作用。结果转移组血清CEA和CA19-9水平分别为(58.42±9.61)μg/L和(72.55±13.73)U/mL,均明显高于其他两组(P<0.05);无转移胃癌组CEA和CA19-9水平分别为(27.41±13.84)μg/L和(33.49±9.37)U/mL,明显高于对照组(P<0.05)。此外,胃癌腹膜转移患者CEA和CA19-9阳性率分别为79.1%和70.9%,胃癌腹膜无转移两种阳性率分别为39.1%和51.8%,两组相比,差异有统计学意义(P<0.05);而对照组中两者标记物检测均为阴性。胃癌腹膜转移患者血清CEA和CA19-9水平与肿瘤的大小、淋巴转移及腹水情况正相关,与肿瘤的分化程度、年龄和性别无关。结论 CEA和CA19-9水平在诊断Ⅳ期胃癌腹膜转移中有着重要作用,二者联合检测可以作为该病临床诊断方法,且操作简单,值得临床推广。
Objective To explore the clinical value of serum carcinoembryonic antigen （CEA） combined with carbohydrate antigen 19-9（CA19-9） in the diagnosis and differential diagnosis of stage Ⅳ gastric cancer peritoneal metastasis .Methods Enzyme coupling adsorption method and chemiluminescence immune assay were used to detec-ted serum CEA and CA19-9 levels in gastric cancer patients with or without peritoneal metastasis （metastasis group and non-metastasis group） and healthy subjects （control group） ,and the results were statistically analyzed .Results Serum levels of CEA and CA19-9 were（58 .42 ± 9 .61）μg/L and（72 .55 ± 13 .73）U/mL in metastasis group ,which were significantly higher than the other two groups（P〈0 .05） ,and those in non -metastasis group were（27 .41 ± 13 .84）μg/L and（33 .49 ± 9 .37）U/mL ,which were higher than control group（P〈0 .05） .The positive rates of serum CEA and CA19-9 were higher than non -metastasis group .In metastasis patients ,serum CEA and CA19-9 levels were correlated with tumor size ,lymph node metastasis and ascites .Conclusion CEA and CA19-9 level could play an important role in the diagnosis of stage Ⅳ gastric cancer peritoneal metastasis ,and combined detection of the two in-dicators could be used for diagnosis .
出处
《检验医学与临床》
CAS
2013年第20期2673-2674,共2页
Laboratory Medicine and Clinic
关键词
癌胚抗原
糖链抗原19-9
Ⅳ期胃癌
腹膜转移
carcinoembryonic antigen
carbohydrate antigen 19-9
stage Ⅳ gastric cancer
peritoneal metastasis
