摘要
目的提高对前列腺基底细胞癌诊断及治疗的认识。方法回顾分析1例前列腺腺样型基底细胞癌的临床资料,并复习相关文献。结果患者因进行性排尿困难伴间断肉眼血尿10年入院。查体见前列腺Ⅱ度增生,表面光滑。血清前列腺特异性抗原(PSA)0.88μg/L;彩色多普勒超声示前列腺4.96 cm×3.55 cm;尿动力学检查异常。误诊为前列腺增生症,经尿道行前列腺电切术后病理诊断为腺样型基底细胞癌,免疫组织化学染色CK34βE-12(+),CK7(-),PSA(-),P504S(-),P63(+),CK20(-),Ki-67(-)。术后1个月行前列腺根治术,随访24个月无复发及转移。结论前列腺腺样基底细胞癌为前列腺腺癌的一个亚型,往往以尿路梗阻症状首发,PSA表达低下。前列腺根治术是首选治疗手段。
Objective To impruve the understanding in diagnosis and treatment of prostatic basal cell carcinoma. Methods Clinical data of a patient with prostatic adenoid basal cell carcinoma was retrospectively analyzed. Results The pafient was ad- mittcd for progressive dysuria and intermittent gross hematuria for 10 years, who had grade I prostatic hyperplasia with smooth sur- face. The serumal prostate specific antigen （PSA） was 0. 88 μg/L; color Doppler ultrasound showed that Ihe prostate size was 4.96 cmx 3.55 cm; urodynamic examination turned to be abnormal. The patient was misdiagnosed as having hyperplasia of pros- tate, and was confirmed with prostatic adenoid basal cell carcinoma by pathologic diagnosis after transt, rethral electrocision, hnmu- nohistuchemical results showed CK34βE-12（ ＋ ） , CKT（ - ）, PSA（ - ） , P504S（ - ） , P63（ ＋ ）, CK20（ - ） and Ki-67（ - ）. The patient underwent prostatic radical resection after transurethral electrocision for one month. The tumor had no recurrence and metas- tasis with 24 months of follow-up. Conclusion Prostatic adenoid basal cell carcinoma is a histological subtype of prostate cancer with the first symptom of urinary obstruction and low prostate-specific antigen. Radical surgery is the preferred therapy method.
出处
《临床误诊误治》
2013年第10期34-36,共3页
Clinical Misdiagnosis & Mistherapy
关键词
前列腺肿瘤
肿瘤
基底细胞
误诊
前列腺增生
Prostatic neoplasm
Tumor, basal cell
Misdiagnosis
Prostatic hyperplasia
