摘要
目的系统评价亚低温辅助治疗重型颅脑损伤的临床疗效。方法计算机检索Wanfang、CNKI、CBM、PubMed、Cochrane Central Register of Controlled Trials（CENTRAL）、EMBASE等数据库,筛选出符合要求的随机对照试验（RCT）,采用RevMan 5.1软件进行Meta分析。结果共纳入符合标准的18篇RCTs,共计1 916例患者。Meta结果显示亚低温组预后良好率（GOS 4~5分）显著高于对照组（OR=2.5,95%CI：2.06~3.02;P〈0.01）;亚低温组患者伤后24 h、3 d及7 d颅内压下降程度优于对照组（P〈0.05）。结论重型颅脑损伤患者在综合治疗的基础上早期行亚低温治疗具有明显的脑保护作用,能降低颅内压,改善患者预后。
Objective To systematically evaluate the efficacy of mild hypothermia for patients with severe traumatic brain injury(sTBI).Methods The databases of Wanfang,CNKI,CBM,PubMed,Cochrane Central Register of Controlled Trials(CENTRAL) and Embase were searched for randomized clinical trials(RCT) studying the efficacy of mild hypothermia for patients with sTBI.The data were analyzed by RevMan software(version 5.1).Results We screened 18 RCTs including 1 916 patients with sTBI.The rate of patients with GOS of 4~5 points was significantly higher in patients treated with mild hypothermia than those without(OR=2.5;95% CI: 2.06~ 3.02;P<0.01).The intracranial pressures of patients treated with mild hypothermia 24 hours,3 days and 7 days after treatment significantly decreased compared with those without(P<0.01).Conclusions Mild hypothermia has significant brain protection for patients with sTBI,since it can decrease intracranial pressure and improve prognosis.
出处
《中国临床神经外科杂志》
2013年第9期532-534,共3页
Chinese Journal of Clinical Neurosurgery
关键词
重型颅脑损伤
亚低温
META分析
Severe traumatic brain injury
Mild hypothermia
Efficacy
Meta-analysis
