摘要
目的 观察高强度聚焦超声 (HIFU )对香猪外阴的损伤作用及愈合过程 ,旨在为外阴营养不良探索新的治疗方法。方法 对 5只小型香猪的外阴进行HIFU(频率 9.84MHz ,声强 110 9W /cm2 )连续扫描定位损伤。HIFU辐照后即刻、3d、7d、14d、2 1d、30d行彩超、病理检查 ,动态监测其损伤变化情况。结果 HIFU可准确定位损伤靶区组织 ,其相临表面皮肤组织不受损伤。HIFU后靶区超声影像学变化与病理学变化一致。结论 HIFU损伤猪外阴安全有效 ,为临床外阴营养不良的治疗提供了实验依据 ;
Objective In order to explore a new method for the treatment of human vulva dystrophy, swine vulva were treated with high intensity focused ultrasound (HIFU).Methods A 9.84 MHz high intensity focused ultrasound at an intensity of 1 109 W/cm 2 with continuous exposure was applied in 5 female swine.After HIFU lesions developed, the outcomes were assessed by color ultrasound and the pathological examination immediately and on day 3,7,14,21 and 30.Results HIFU was competent for damaging precisely the target tissue of the vulva and disrupting irreversibly the cellular structure in the focal region leaving the intact surface skin of the target region. A change of ultrasound in the focused region was coincident with that of the pathology.Conclusions HIFU has the powerful effect of accurately destroying vulva tissue and keeping the surface skin intact.The results provided an experimental basis for the clinical treatment of vulva dystrophy. Color ultrasound will become a useful tool in monitoring the outcome after HIFU treatment.
出处
《中华超声影像学杂志》
CSCD
2000年第9期569-571,共3页
Chinese Journal of Ultrasonography
基金
国家"九五"重点科技攻关项目基金!(969050201)
关键词
高强度聚焦超声
猪
外阴损伤
治疗
High intensity focused ultrasound
Swine
Vulva lesion
