摘要
目的探讨孕中期超声筛查在诊断唐氏高风险胎儿中的作用和意义。方法对15~20周孕妇抽血进行血清标记物甲胎蛋白（AFP）、β绒毛膜促性腺激素（β-hCG）筛查,以1：300为切割值,对唐氏高风险者建议孕中期超声筛查及羊膜腔穿刺。结果血清筛查唐氏高风险682例,其中184例同意羊水穿刺,发现21三体4例,阳性率2.17%。孕中期超声筛查635例,发现胎儿异常标记37例,异常检出率5.83%。其中21例分娩,16例引产。结论孕中期超声筛查可检出胎儿结构畸形和软指标异常,联合血清标记物和羊水穿刺可有效减少唐氏儿的出生。
Objective To investigate the function and significance of ultrasound screening for detecting Down＇s high-risk fetal during the second trimester. Methods The examinations of serum markers of alpha-fetal protein（AFP）and human chorionic gonadotrophin（尾-hCG）were given to pregnant women with a gestational age of 15-20 weeks. When the number exceed 1：300,it was regarded as high risk of Down＇s. Every high-risk fetal was suggested to have ultrasound screening and amniocentesis in middle stage of pregnancy. Results Of the 682 cases received serum screening, 184 cases accepted amniocentesis. Among them, 4 cases were found with 21-trisomy syndrome,the positive rate was 2.17%. Of the 635 cases received ultrasound screening during the second trimester,37 fetals were found with abnormal markers,the detection rate was 5.83%. Of which, there were 21 cases of delivery and 16 cases of induced labor. Conclusion Ultrasound screening in the second trimester can detect fetal structure malformation and soft marker abnormalities,which combined with the examination of serum markers and amniocentesis can reduce the birth of Down＇s fetal effectively.
出处
《中外医疗》
2013年第27期18-19,共2页
China & Foreign Medical Treatment
关键词
唐氏高风险
胎儿
孕中期
超声筛查
Down＇s high risk
fetal
middle stage of pregnancy
ultrasound screening
