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激肽释放酶-激肽系统对心梗后心肌细胞灌注的影响 被引量：4

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摘要 激肽释放酶-激肽系统包含多种具有血管活性的多肽分子,这些多肽分子在心脏分布丰富,在心肌梗死(心梗)后可以通过多种途径改善心室重构、缩小心肌梗死面积、减少心肌细胞凋亡、抑制心肌纤维化,从而改善心梗后心功能。已有研究表明,激肽可以通过B2受体增加冠状动脉血流。近年来大量研究提示,激肽及其B1、B2受体可通过多种途径促进心脏血管再生;在增加心肌细胞灌注的同时,激肽可以通过多种途径来减少缺血-再灌注带来的损伤,进一步发挥对心梗后心脏的保护作用。作者对激肽释放酶-激肽系统在心梗后心细胞灌注中的作用作一综述。
作者 黄长根 姚玉宇 马根山
机构地区 东南大学医学院心血管病研究所 东南大学附属中大医院心血管内科
出处 《东南大学学报（医学版）》 CAS 2013年第5期626-630,共5页 Journal of Southeast University(Medical Science Edition)
基金 国家自然科学基金资助项目(30871071 81070085)
关键词 激肽释放酶-激肽系统 心肌梗死 心脏血管再生 心肌细胞灌注 缺血-再灌注 文献综述
分类号 R541.4 [医药卫生—心血管疾病]
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参考文献39

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二级参考文献43

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共引文献18

同被引文献54

引证文献4

二级引证文献18

东南大学学报（医学版）
2013年 第5期

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