摘要
目的探讨胺碘酮治疗急诊冠心病心律失常的临床应用价值。方法回顾性分析2010年11月至2012年11月三门峡市中医院收治的90例急诊冠心病心律失常患者,将这些患者按照不同的治疗方法分为两组,各45例,在常规治疗的基础上采用不同的治疗方法,对照组采用普罗帕酮治疗,观察组采用胺碘酮治疗,一个疗程后,对两组患者的24h内房颤转复率,临床疗效和住院期间的病死率和梗死率进行比较和观察。结果观察组45例,显效37例,有效5例,无效3例;对照组45例,显效28例,有效8例,无效9例。观察组有效率为93.3%,与对照组80.0%,差异有统计学意义(P<0.05);观察组胸痛复发1例,复发率为2.22%,与对照组(8.90%,4/45)比,差异有统计学意义(P<0.05);观察组用药24h后的心室率为(73±6)次/分钟,相较于对照组的(89±9)次/分钟,有明显的好转(P<0.05)。观察组在24h内的房颤转复率、临床疗效、住院期间的病死率以及再梗死率方面显著优于对照组(P<0.05);且观察组治疗后HR明显降低,恢复至正常范围(P<0.01);QTc显著增高(P<0.01);QTd显著减少(P<0.01)。结论胺碘酮能迅速促进急诊冠心病心律失常患者恢复窦性心律,较为安全、可靠,值得临床推广。
Objective To study the clinical effect of amiodarone in the treatment of arrhythmia in emergent coronary heart disease（CHD）.Methods From Nov.2010to Nov.2012,90patient with emergent CHD arrhythmia were divided into control group（45cases）,receiving routine treatment combined with propafenone,and observation group（45cases）,receiving routine treatment combined with amiodarone.Indicators,including atrial fibrilation（AF）converting rate within 24hours,clinical curative effect,in-hospital mortality and infarction rate were compared between the two groups.Results In observation group,the number of patients with markedly effectiveness,effectiveness and non-effectiveness were 37,5and 3cases,and those of control group were 28,8and 9cases.The effectiveness rate of observation group was 93.3%,higher than the 80.0%of control group（P0.05）.The recurrence rate of chest pain was 2.22%（1/45）in observation group,lower than the 8.90%（4/45）in control group（P 0.05）.The ventricular rate 24hours after treatment in observation group was（73±6）times/min,significantly lower than the（89±9）times/min of control group（P0.05）.The AF converting rate with 24hours,clinical effectiveness,in-hospital mortality and infarction rate in observation group were superior to control group（P0.05）.The HR in observation group were significantly decreased after treatment and restored to the normal range（P0.01）,QTc were significantly increased（P0.01）and QTd were significantly reduced（P0.01）.Conclusion Amiodarone could quickly promote the restoring of sinus rhythm in patients with emergent CHD arrhythmia,and could be relatively safe,reliable and worthy for clinical promotion.
出处
《检验医学与临床》
CAS
2013年第19期2562-2563,2565,共3页
Laboratory Medicine and Clinic
关键词
胺碘酮
冠心病
快速心律失常
临床效果
amiodarone
coronary heart disease
rapid arrhythmia
clinical effect
