摘要
目的探讨CD14、CD11b、CD64、CD4在鉴别诊断单核细胞相关性急性髓细胞性白血病(AML)(M4/M5)中的应用评价。方法采用流式细胞术分析420例急性髓细胞性白血病患者骨髓或外周血标本的免疫表型。结果在单核细胞相关性AML(M4/M5)中CD14、CD11b、CD64和CD4的表达率依次为45.4%、46.1%、83.0%和62.4%。与非单核细胞相关性急性髓细胞性白血病相比表达率高,差异有统计学意义(P<0.01)。其中CD14、CD11b特异性高(100%和91.8%),CD64敏感性高(83.0%)。结论 CD14、CD11b、CD64、CD4有助于M4/M5与其他AML各亚型的鉴别诊断。
Objective To study the differentially diagnostic value of CD14,CD11b,CD64and CD4in monocyte lineage relative acute myeloid leukemia（M4/M5）.Methods Peripheral blood and bone marrow of 420cases with acute myeloid leukemia was analyzed by flow cytometry.Results In monocyte lineage relative acute myeloid leukemia,the expression percentages of CD14,CD11b,CD64and CD4were 45.4%,46.1%,83.0% and 62.4%,which were significantly higher than patients with non-monocyte lineage relative acute myeloid leukemia（P0.01）.CD14and CD11b were with high specificity（100% and 91.8%）and CD64 was with high sensitivity（83.0%）.Conclusion Detection of CD14,CD11b,CD64and CD4could be helpful for the differential diagnosis between M4/M5 and other types of acute myeloid leukemia.
出处
《检验医学与临床》
CAS
2013年第19期2520-2521,2523,共3页
Laboratory Medicine and Clinic
