摘要
目的:探讨心脏血管肉瘤伴肺转移的临床病理特点。方法:对我院收治的2例心脏血管肉瘤伴肺转移患者的临床表现、组织形态学及免疫组化进行分析,并复习相关文献。结果:患者早期临床表现为胸闷或心悸症状,后期均出现咯血。光镜下可见瘤细胞呈多形性,呈实性条索、团块状排列或围成不规则的、相互吻合的管腔,伴出血坏死。免疫组织化学染色显示肿瘤细胞CD31、CD34和Vimentin阳性;CK、FⅧ和TTF-1阴性。结论:心脏血管肉瘤伴肺转移需要和纵隔肿瘤伴肺转移进行鉴别,免疫组织化学是确诊的依据。其临床表现无明显特异性,早期诊断困难,疾病进展迅速,预后极差。
Objective：To research the clinical and pathological features of cardiac angiosarcoma with pulmonary metastases.Methods：The clinical manifestations,histopathological features and immunohistochemical results were analyzed in two cases of cardiac angiosarcoma with pulmonary metastases in the hospital,with review of the related literatures.Results：The early clinical symptoms of patients were chest tightness and palpitations,later both of them had hemoptysis.Microscopically,the lesion was consisted of a number of spindle cells and epithelial cells,with extensive areas of necrosis and haemorrhage.These tumor cells formed rudimentary vascular channels and these neoplastic channels were irregular in shape.Immunohistochemically,these tumor cells were positive for CD31,CD34 and Vimentin;negative for CK,FⅧ and TFF-1.Conclusion：Cardiac angiosarcoma with pulmonary metastases should be differentiated from mediastinal tumor with pulmonary metastases,immunocytochemieal studies are essential to the diagnosis.Early diagnosis is difficult because of nonspecific clinical symptoms.The rapid and aggressive behavior of cardiac angiosarcoma results in poor prognosis.
出处
《中日友好医院学报》
2013年第5期272-275,280,F0004,共6页
Journal of China-Japan Friendship Hospital
关键词
心脏肿瘤
血管肉瘤
肺转移
cardiac tumor
angiosarcoma
pulmonary metastases
