摘要
目的观察中西医结合疗法治疗糖尿病肾病(diabetic nephropathy,DN)的疗效及建立其综合疗效评价体系。方法纳入MogensenⅢ、Ⅳ期DN患者120例,将其随机分为治疗组(芦黄参花胶囊和福辛普利联合治疗)和对照组(单用福辛普利治疗),疗程为3个月。比较两组的临床疗效及中医证候疗效,观察治疗前后DN患者尿白蛋白排泄率(urinary albumin excretion rate,UAER)、肾功能、血压、血糖、血脂水平,采用世界卫生组织生存质量量表简表评价患者治疗前后的生存质量。结果对于MogensenⅢ、Ⅳ期DN患者,治疗组临床疗效及中医证候疗效均显著高于对照组(P<0.05);治疗组在降低MogensenⅢ期DN患者UAER及血清肌酐、尿素氮水平,提高MogensenⅢ、Ⅳ期DN患者生理健康、心理健康、总的生存质量和满意度评分方面显著优于对照组(P<0.05,或P<0.01)。两组均未见明显不良反应。结论芦黄参花胶囊和福辛普利联合治疗可有效降低早期DN患者尿蛋白,改善肾功能,提高患者的生存质量,本研究可为DN的防治提供新的疗效评价体系。
Objective To observe the therapeutic effect of integrated traditional Chinese and Western med- icine therapy in the treatment of diabetic nephropathy （DN） and to establish a comprehensive evaluation system for the treatment outcome in DN patients. Methods A total of 120 patients with Mogensen stage Ⅲ and Ⅱ DN were included in the study. They were randomly divided into treatment group and control group. The treatment group received Lu Huang Shen Hua （LHSH） Capsules combined with fosinopril, while the control group received fosinopril alone. The course of treatment was 3 months for both groups. The two groups were compared in terms of clinical outcome and improvement in traditional Chinese medicine （TCM） syndrome. Before and after treatment, the urinary albumin excretion rate （UAER）, renal function, blood pressure, blood glucose, and blood lipid were measured, and the quality of life （QOL） was assessed using the World Health Organization＇s Quality of I.ife Questionnaire-Brief Version. Results Compared with those in control group, the patients with Mogensen stage Ⅲ and Ⅳ DN in treatment group had a significantly better clinical outcome （P〈 0.05） and a significantly more improvement in TCM syndrome （P〈0.05）. After treatment, the patients with Mogensen stage IlI DN in treatment group had significantly lower UAER, serum creatinine, and blood urea nitrogen than their counterparts in control group （P^0.05 or P〈~0.01）, and the patients with Mogensen stage 11] and 1~＇ DN in treatment group had significantly higher scores of physiological health, psychological health, overall Q（）L, and satisfaction than their counterparts in control group （P^0.05 or P〈~0.01）. No adverse events were seen in either group. Conclusion I.HSH Capsules combined with fosi nopril can effectively reduce urinary protein excretion and improve renal function and QOL in patients with early DN. This study provides a new evaluation system for the treatment outcome in DN patients.
出处
《安徽中医学院学报》
CAS
2013年第5期38-42,共5页
Journal of Anhui Traditional Chinese Medical College
关键词
糖尿病肾病
芦黄参花胶囊
福辛普利
肾功能
血脂
生存质量
diabetic nephropathy
Lu Huang Shen Hua Capsule
fosinopril
renal function
blood lipid
quality of life
