摘要
利用间充质干细胞(menchymal stem cells,MSCs)的多向分化能力,将其诱导成为内皮细胞(endothelial cells,ECs),可解决血管组织工程中自体血管细胞作为种子细胞所面临的细胞来源及成体细胞增殖能力有限的问题.MSCs可从多种组织中分离获得,目前应用于血管组织工程的3种MSCs主要源于骨髓、脂肪和肌肉.MSCs的分化可由多种刺激触发,在其向ECs的分化过程中生长因子、支架性质和机械应力等因素起着重要的作用.而以MSCs分化为ECs为基础的组织工程血管在动物模型中展现出促血管生成能力和良好的通畅性,但目前其在临床上的应用较少,需进一步研究,并有许多问题仍待探究.
Endothelial cells （ECs）-based repair has been applied to vascular tissue engineering and thera- peutic angiogenesis for years. Mesenchymal stem cells （MSCs） can overcome the source deficiency and pro- liferative limitation of autologous ECs, due to its potential to differentiate into ECs. Although MSCs can be isolated from a variety of tissues, bone marrow, adipose tissue and muscle are the main sources of MSCs used in vascular tissue engineering aiming at promoting vascularization. The differentiation from MSCs to ECs, is composed of a series of intricate processes triggered by a bunch of stimuli, including growth factors, vascular scaffold and mechanical stress. There are numerous reports evincing that the differentiation can take place in vitro and the obtained ECs possess great proangiogenic ability in animal models. Although some clinical studies based on the ECs differentiation from MSCs have been reported in the treatment of cardio- vascular diseases, many problems remain to be studied.
出处
《生命科学研究》
CAS
CSCD
北大核心
2013年第5期458-464,共7页
Life Science Research
基金
福建省科技计划重点项目(2010Y0020)
关键词
间充质干细胞
分化
内皮细胞
血管组织工程
menchymal stem cells
differentiation
endothelial cells
vascular tissue engineering
