摘要
目的:本文旨在研究脉冲电磁场对糖尿病大鼠所患外周神经病的影响。方法:成年SD大鼠随机分为3组(8只/组):正常组、糖尿病组以及糖尿病+脉冲电磁场组。糖尿病模型由链脲唑霉素诱导,实验组饲养过程中采用脉冲电磁场辐照7wk(8 h/d)。通过行为学指标的检测对大鼠糖尿病神经病变的迹象和特征进行评估。结果:经过7wk的观测,我们发现脉冲电磁场能够显著降低糖尿病大鼠对于机械刺激和热刺激的敏感性。结论:脉冲电磁场的治疗能够缓解糖尿病大鼠动物模型的外周神经病变的发展,并且脉冲电磁场对于损伤的神经可能有的修复作用,脉冲电磁场可称为一种潜在的非侵入式的治疗手段来治疗糖尿病外周神经病。
Objective： The present study was designed to investigate effects of pulsed electromagnetic field （PEMF） to peripheral diabetic neuropathy （DPN） in diabetic rats Methods： Adult male Sprague-Dawley rats were randomly divided into three groups （eight in each group）： the non-diabetic control group （Control）, diabetes mellitus with PEMF exposure group （DM＋PEMF） which were subjected to daily 8-h PEMF exposure for 7 weeks and diabetes mellitus with sham PEMF exposure group （DM）. Signs and symptoms of DPN in STZ-treated rats were investigated by using behavioral assays. Results： During 7-week experimental observation, we found that PEMF stimulation attenuated the development of the abnormalities observed in STZ-treated rats with DPN, which were demonstrated by increased hind paw withdrawal threshold to mechanical and thermal stimuli. Conclusions： The current study demonstrates that treatment with PEMF may prevent the development of abnormalities observed in animal models for DPN. It is suggested that PEMF would be a potentially promising non-invasive therapeutic tool for the treatment of diabetic neuropathy.
出处
《中国医学物理学杂志》
CSCD
2013年第5期4431-4433,共3页
Chinese Journal of Medical Physics
基金
国家自然科学基金(31000381
51077128)
关键词
脉冲电磁场
糖尿病
周围神经病变
pulsed electromagnetic field
diabetes mellitus
peripheral neuropathy
