期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

低危妊娠滋养细胞肿瘤的治疗进展 被引量：4

暂未订购
导出
摘要 由于妊娠滋养细胞肿瘤（gestational trophoblast-ic neoplasia，GTN）对化疗的高度敏感性和HCG作为肿瘤标志物的理想性，因此GTN是迄今预后最好的恶性肿瘤。目前其治疗主要根据预后评分给予其分层治疗。低危GTN治愈率将近100％ [1-3]，而高危患者也可达86％[2]，因此对于低危GTN患者来说，治疗方案的选择更需考虑其生活质量，近年来对此比较关注，现综述如下。
作者 吴晓东 吕卫国
机构地区 浙江大学医学院附属妇产科医院
出处 《妇产与遗传（电子版）》 2013年第2期55-58,共4页 Obstetrics-Gynecology and Genetics (Electronic Edition)
关键词 妊娠滋养细胞肿瘤 分层治疗 低危 高危患者 肿瘤标志物 GTN 恶性肿瘤 生活质量
分类号 R737.33 [医药卫生—肿瘤]
  • 相关文献

参考文献19

  • 1Chalouhi GE,Golfier F,Soignon P. Methotrexate for 2000 FIGO low-risk gestational trophoblastic neoplasia patients:efficacy and toxicity[J].Am J Obstet Gynecol,2009,(06):643el-643e6.
  • 2Ngan S,Seckl MJ. Gestational trophoblastic neoplasia management:an update[J].Curr Opin Oncol,2007,(15):486-491.
  • 3Rodriguez N,Goldstein DP,Berkowitz RS. Treating gestational trophoblastic disease[J].Expert Opin Pharmacother,2010,(18):3027-3039.
  • 4Ngan HY,Kohorn EI,Cole LA. Trophoblastic disease[J].Int J Gynaecol Obstet,2012,(Suppl 2):S130-S136.
  • 5Hoekstra AV,Lurain JR,Rademaker AW. Gestational trophoblastic neoplasia:treatment outcomes[J].Obstet Gynecol,2008,(2ptl):251-258.
  • 6Berkowitz RS,Goldstein DP. Current advances in the management of gestational trophoblastic disease[J].Gynecol Oncol,2013,(01):3-5.
  • 7Osborne R J,Filiaci V,Schink JC. Phase Ⅲ trial of weekly methotrexate or pulsed dactinomycin for low-risk gestational trophoblastic neoplasia:a gynecologic oncology group study[J].J Clin Oncol,2011,(07):825-831.
  • 8Lybol C,Sweep FC,Harvey R. Relapse rates after two versus three consolidation courses of methotrexate in the treatment of low-risk gestational trophoblastic neoplasia[J].Gynecol Oncol,2012,(03):576-579.
  • 9McNeish IA,Strickland S,Holden L. Low-risk persistent gestational trophoblastic disease:outcome after initial treatment with low-dose methotrexate and folinic acid from 1992 to 2000[J].J Clin Oncol,2002,(07):1838-1844.
  • 10Garrett AP,Garner EO,Goldstein DP. Methotrexate infusion and folinic acid as primary therapy for nonmetastatic and low-risk metastatic gestational trophoblastic tumors.15 years of experience[J].{H}Journal of Reproductive Medicine,2002,(05):355-362.

同被引文献44

  • 1杨秀玉.必须重视妊娠滋养细胞肿瘤的规范化治疗[J].中华妇产科杂志,2005,40(2):73-75. 被引量：51
  • 2陈亚侠,沈源明,钱建华,谢幸.采用甲氨蝶呤初次化疗方法对低危妊娠滋养细胞肿瘤疗效及影响因素的分析[J].中华医学杂志,2005,85(30):2109-2112. 被引量：9
  • 3Lurain JR.Gestational trophoblastic diseaseⅡ:classification and management of gestational trophoblastic neoplasia.Am J Obstet Gynecol,2011;204(11):8.doi:10.1016/j.ajog.2010.06.072.
  • 4FIGO Committeeon Gynecologic Oncology.Current FIGO staging for cancer of the vagina,fallopian tube,ovary,and gestational trophoblastic neoplasia.Int J Gynaecol Obstet,2009;105(1):3-4.
  • 5Osborne RJ,Filiaci V,Schink JC,et al.PhaseⅢtrial of weekly methotrexate or pulsed dactinomycin for low-risk gestational trophoblastic neoplasia;a gynecologic oncology group study.J Clin Oncol,2011;29(7):825-831.
  • 6Matsui H,Suzuka K,Yamazawa K,et al.Relapse rate of patients with low-risk gestational trophoblastic tumor initially treated with single-agent chemotherapy.Gynecol Oncol,2005;96(3):616-620.
  • 7Wang S,An R,Han X,et al.Combination chemotherapy with 5 -fluorouracil,methotrexate and etoposide for patients with high-risk gestational trophoblastic tumors:a report based on our 11-year clinical experiences.Gynecol Oncol,2006;103(3):1105-1108.
  • 8Goldstein DP,Berkowitz RS.Current management of gestational trophoblastic neoplasia.Hematol Oncol Clin North Am,2012;26(1):111-131.
  • 9MaestáI,Berkowitz RS,Goldstein DP,et al.Relationship between race and clinical characteristics,extent of disease,and response to chemotherapy in patients with low-risk gestational trophoblastic neoplasia.Gynecol Oncol,2015;138(1):50-54.
  • 10Zhao Y,Zhang W,Duan W.Management of gestational trophoblastic neoplasia with 5-fluorouracil and actinomycin D in northern China.J Reprod Med,2009;54(2):88-94.

引证文献4

二级引证文献15

妇产与遗传（电子版）
2013年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部