摘要
目的 探讨眼型重症肌无力 (MG)患儿免疫状态及其在大剂量丙种球蛋白 (HDIVIg)静注治疗前后的变化 ,观察 HDIVIg治疗的临床效果。方法 用 EL ISA法及酶联法检测 2 0例 MG患儿接受 HDIVIg治疗前后的免疫指标 ,对乙酰胆碱受体抗体 (Ach Rab)、血清可溶性白细胞介素 受体 (s IL - 2 R)进行了对比观察 ,并对其临床作用时间进行了观察。结果 该组患儿治疗有效率 10 0 % ,复发率 10 %。治疗前后 Ach Rab、s IL - 2 R均有明显改变。结论 眼型 MG患儿存在免疫紊乱 ,HDIVIg治疗该病显效快、复发率低、疗效满意。
Objectives To study on clinical effect and immune parameters in 20 children with myasthensia gravis(MG) before and after treatment with high does intravenous injection of gamma globulin(HDIVIg) was reported in the paper. To investigate changes in immune parameters and clinical effect in patients with MG before and after treatment and to observe clinical effect of HDIVIg. Methods Analyzed comparetively changes of AchRab and sIL 2R in serum before and after treatment with HDIVIg in 20 Children cases with MG. Results Level of sIL 2R and AchRab in patient sera was higher than those of controlling sroup(p<0.01),but dicreased dramakably a month later after treatment with HDIVIg(p<0.01);serum level of sIL 2R and AchRab also dicreased in varied degree.Clinically effective rate of HDIVIg therapy was 100%,average period of reliefe was 3.70±1.85d,recurrent rate was 2 in 20 cases(10%) after following up for 8 months. Conclusions Is that immune function in children patients with MG is disturbed,effect of treatment with HDIVIg apperars early and recurrence is at lower rate.
出处
《中风与神经疾病杂志》
CAS
CSCD
北大核心
2000年第5期295-296,共2页
Journal of Apoplexy and Nervous Diseases
基金
吉林省科委资助课题!(95 35 5 8-1)
