摘要
目的 评估出生后早期佝偻病预防的方法。方法 以医院为基础 (Hospitalbased)的双盲随机对照试验方法 ,对 149例新生儿单次给维生素D疗法 (对照组 15 6例 )的预防效果进行了评估。结果 ①预防组的骨碱性磷酸酶 1月龄和 3月龄异常率较对照组显著降低 ,预防组的 3月龄颅骨软化发生率显著降低。②预防组的上呼吸道感染发生率在 3月龄和 10月龄时较对照组显著降低。③预防组的 3月龄和 10月龄身长较对照组稍高(有统计学差异 )。④预防组发生惊厥和可疑惊厥病例稍多 ,但尚无统计学显著意义 ,两组发生惊厥和可疑惊厥病例的血钙基本正常。⑤经检查 :失访率较低 (<6 % ) ,分组后的均衡性较好 ,查体的重复性较好 (Kappa值 >0 75 )。⑥初步的卫生统计学分析提示 :本方法的NNT为 12人 ,每预防 1例佝偻病约需人民币 2 0元 ,每减少 1个生命质量调整寿命年损失约需人民币 6 6 7元。结论 出生后单次预防有一定的可行性。
Objective\ To investigate the method in the prevention of early stage rickets.Methods\ By double-blind randomly controlled study,the preventive effects of single-dosed vitamin D on rickets was evaluated in 322 neonates.Single dose of vitamin D was given to 149 neonates,while 156 were served as control.Results\ ①Bone alkaline phosphatase(BALP)in preventive group was significantly lower than that in controls.②The upper respiratory infection rates at the third and tenth month in preventive group decreased significantly than those in controls.③The body height in preventive group at the third and tenth month was significantly higher than that in controls.④The occurrence of convulsion in preventive group was slightly frequent than that in control group,but had no significant difference.⑤The trial had the characters of low lost follow-up rate(<6%),well balanced grouping and well repetition(Kappa>0.75).⑥Primary statistical analysis showed that there were 12 NNT in the study.20 Yuan was needed for the prevention of the rickets,while 66.7 yuan were lost for on reduced life-span year.Conclusion\ Single dose vitamin D supplement may be of value to the prevention of rickets.s:IFNα could inhibit the proliferation of HL 60 cells,especially accompanied with the ATRA IFNα not only induce the differentiation but also promote the differentiation of HL 60 cells or ATRA resistant HL 60 cells ATRA resistant HL 60 cells post treatment with IFNα were sensitive to ATRA Conclusion:Effect on differentiation of HL 60 cells was enhanced by IFNα IFNα also reverse the resistance of ATRA resistant HL 60 cells to ATRA Key words IFNα HL 60 cell Resistance
出处
《中国实用儿科杂志》
CSCD
北大核心
2000年第11期676-678,共3页
Chinese Journal of Practical Pediatrics
基金
国际流行病工作网 (INCLEN)资助! (资助批准号 :10 0 496 12 0 2 )
关键词
维生素D缺乏性佝偻病
双盲试验
预防
儿童
Vitamin D deficiency rickets\ Randomized controlled tries(RCT)\ Double blind\ Prevention
