摘要
采用实验性蛛网膜下腔出血 (SAH)大鼠模型 ,以荧光分光光度法研究尼莫地平 (Nim)对 SAH后脑皮质内去甲肾上腺素 (NE) ,多巴胺 (DA) ,5-羟色胺 (5- HT)和 5-羟吲哚乙酸 (5- HIAA)等水平的影响 .结果显示 ,SAH后 48h脑皮质内 NE,5- HT和5- HIAA的水平均显著升高 ,Nim(1 .0 mg· kg-1ip,术前 1 h开始注射 ,每 6h重复 1次 ,共计 9次 )可明显降低 SAH后脑皮质内 NE ,5- HT和 5-HIAA的水平 ;DA的水平均无明显变化 .结果说明Nim可有效改善
The experimental rat subarachnoid hemorrhage(SAH) model was employed to investigate the effect of nimodipine (Nim) on levels of monoamine neurotransmitters in the cerebral cortex 48 h after SAH. The levels of norepinephrine(NE), dopamine(DA), 5 hydroxytryptamine(5 HT) and 5 hydroxyindoleacetic acid(5 HIAA) were measured by fluorospectrophotometry. The result showed an extensive increase in levels of NE, 5 HT and 5 HIAA in the cerebral cortex at 48 h after SAH. DA had a tendency to increase without significance. Nim (1 mg·kg -1 ip, firstly at 1 h before SAH, other 8 repeated injections given at 6 h intervals.) could effectively decrease the concentration of NE, 5 HT and 5 HIAA in the cerebral cortex after SAH. The data suggest that the Nim significantly ameliorate the metabolic disorder of monoamine neurotransmitters in the cerebral cortex after SAH.
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
2000年第6期464-466,共3页
Chinese Journal of Pharmacology and Toxicology
