摘要
目的 研究盐酸洛美沙星葡萄糖注射液的制备工艺和质量标准 .方法 将盐酸洛美沙星制成输液剂 ,含量测定采用紫外分光光度法 ,在 2 87nm波长处 ,以 0 .1m ol· L- 1 盐酸为溶剂 .结果 盐酸洛美沙星的紫外吸收系数 E1 %1 cm为 981,平均回收率为 99.78% ,RSD=0 .2 0 % .四批成品均符合质量要求 .结论 盐酸洛美沙星葡萄糖注射液的处方和工艺可行 ,质量稳定 .
AIM To investigate a procedure for lomefloxacin hydrochloride /glucose injection preparation and its quality standard. METHODS Procedure for its preparation was according to infusion injection and the content of lomefloxacin in the injection was determined in 0.1 mol·L -1 hydrochloric acid by ultraviolet spectrophotometer. The wavelength of detection was 287 nm. RESULTS Absorption coefficient(E 1%_ 1 cm)of lomefloxacin hydrochloride was 981, the average recovery was 99.78%, RSD was 0.20%. The quality of its four batches prepared was in conformity with the requirements. CONCLUSION Both the formula and preparation procedure for lomefloxacin hydrochloride and glucose injection are feasible and its quality is stable.
出处
《第四军医大学学报》
2000年第12期1552-1554,共3页
Journal of the Fourth Military Medical University
关键词
盐酸洛美沙星
质量控制
葡萄糖注射液
制备
lomefloxacin hydrochloride
spectrophotometry,ultraviolet
quality control
