摘要
目的 研究早期应用小儿氨基酸对早产小于胎龄儿宫外生长发育的影响.方法 选取2011年6月至2013年5月本院新生儿重症监护室（NICU）住院的106例早产小于胎龄儿为研究对象,将患儿按随机数字表法分为2组：治疗组（53例,T组）和对照组（53例,C组）；再将T组和C组按胎龄和出生体重分为4个亚组[≥34周组（T1组,C1组）,＜34周组（T2组,C2组）；＜1.5 kg组（T3组,C3组）,≥1.5 kg组（T4组,C4组）],观察生后6h和生后12 h应用小儿氨基酸对患儿宫外生长的影响,以及相关生化指标的影响.结果 治疗2周后,T组患儿头围和体重增长值高于C组（P ＜0.05或P＜0.01）,恢复出生体重时间明显缩短（P＜0.05或P＜0.01）；T组宫外发育迟缓（EUGR）发生率低于C组（P＜0.01）,T组血尿素氮（BUN）显著高于C组（P＜0.01）,两组血ALT、天门冬氨酸氨基转移酶（AST）、总胆红素（TBIL）、胆固醇（CH）和甘油三酯（TG）水平比较差异均无统计学意义（P＞0.05）.C组中C4与T4的丙氨酸氨基转移酶（ALT）比较差异有统计学意义（P＜0.01）.不同出生体重组中,治疗2周后,T组患儿血BUN水平高于C组（P＜0.05）,但两组血AST、TBIL、CH、TG水平比较差异均无统计学意义（P＞0.05）；C4组EUGR发生率高于T4组（P＜0.05）.结论 早产小于胎龄儿生后6h开始应用小儿氨基酸（1 g/kg）,是安全的,可促进头围和体重的增长、缩短出生体重恢复时间和降低宫外生长发育迟缓发生率.
Objective To explore the effect of early application of pediauic amino acids on extrauterine growth and development of preterm and small for gestational age infants.Methods A total of 106preterm and small for gestational age infants was selected in our NICU from June 2011 to May 2013,and randomly divided into two groups：treatment group （group T） and control group （group C）.Next,each group was divided into two subgroups according to gestational age and birth weight.Such as ≥34W group （group T1,group C1）,〈 34W group （group T2,group C2）,〈 1.5 kg group （group T3,group C3） and ≥ 1.5 kg group （group T4,group C4）.They were observed the effect of extrauterine growth and correlative serum biochemical indicators with application of pediatric amino acid in postnatal 6 hours and 12 hours.Resuits After 2-week treatment,the head circumference and weight growth of group T were higher than that of group C （P 〈 0.05,or P 〈 0.01）,and the time of birth weight recovery was significantly shortened（P 〈 0.05,or P 〈 0.01）.The incidence rate of extrauterine growth retardation（EUGR） in the group T was lower than that in group C,there is significantly statistical differences（P 〈 0.01）.The concentration of blood urea nitrogen （BUN） in group T was obviously increased than that in the group C（P 〈0.01）.The levels of ALT,aspartate aminotransferase （AST）,total bilirubin （TBIL）,cholesterol （CH） and triglycerides （TG） were not different between the group T and group C.The comparison of alanine aminotransferase （ALT） levels were statistically significant between group C4 and group T4.In the different gestational age groups,the concentration of BUN in group T was obviously higher than that in the group C after 2-week treatment（P 〈0.05）,the levels of AST,TBIL,CH and TG were not different between the group T and group C （P 〉 0.05）.The incidence rate of EUGR in the 4th group C was increased significantly than that in the 4th group T（P 〈0.05）.Conclusions The preterm and small for gestational age infants were safe after the pediatric amino acid was used at the 6 h after birth.Amino acid can promote growth of head circumference and weight,shorten the birth weight recovery time and reduce the incidence of EUGR.
出处
《中国医师杂志》
CAS
2013年第8期1037-1040,共4页
Journal of Chinese Physician
关键词
氨基酸类
治疗应用
生长障碍
治疗
婴儿
小于胎龄
婴儿
早产
Amino acids/therapeutic use
Growth disorders/therapy
Infant, small for gestationalage
Infant, premature
