摘要
目的探讨E-cadherin、Ki-67在乳腺髓样癌中表达及临床病理意义。方法采用免疫组织化学方法检测42例乳腺髓样癌中E-cadherin、Ki-67的表达。结果 E-cadherin和Ki-67蛋白表达阳性率在乳腺髓样癌中表达分别为81%(34/42)和76.2%(32/42)。E-cadherin表达阳性率与淋巴结转移呈显著相关(P<0.05),而与患者年龄、肿瘤大小及是否远处转移无关(P>0.05);Ki-67表达及阳性程度随着病理组织学分级、淋巴结转移而增加。结论 E-cadherin和Ki-67蛋白的表达差异是影响乳腺髓样癌预后的重要原因。
Objective To explore expression of E-cadherin and Ki-67 protein and clinical Pathological significance in the Medullary Carcinoma of Breast. Methods Using immunohistochemical method to detect the expression of E-cadherin and Ki-67in 42 cases of mammary medullary carcinoma. Results E-cadherin and Ki-67 protein expression positive rate in the medullary carcinoma of breast was 81%（34/42） and 76.2%（32/42）.E-eadherin expression positive rate was significantly correlated with lymph node metastases（P 〈 0.05）, and regardless of with age of the patient, tumor size, distant metastasis（P ^- 0.05）.Ki-67 expression rate and positive degree increased with pathology histology classification,lymph node metastasis. Conclusion E-adherin and Ki-67 protein expression difference is the important reasons influence breast medullary carcinoma prognosis.
出处
《中国医药科学》
2013年第19期123-124,139,共3页
China Medicine And Pharmacy
