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阿托伐他汀强化治疗对冠心病患者外周血管易损斑块的影响 被引量：10

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摘要 目的观察阿托伐他汀联合阿司匹林控制冠心病患者周围血管易损斑块的效果。方法冠心病患者68例随机分为常规剂量阿托伐他汀治疗组(对照组)与强化阿托伐他汀治疗组(观察组)各34例,2组均给予阿司匹林肠溶片100mg/次,1次/d,口服,对照组给予阿托伐他汀20 mg/次,1次/d,睡前口服;观察组给予阿托伐他汀40 mg/次,1次/d,睡前口服。2组均连续服用24个月,观察2组治疗前、后颈总动脉内径(common carotid artery diameter,CCAD)、颈动脉内-中膜厚度(carotid intima-media thickness,CIMT)、斑块体积及血脂变化情况。结果 2组治疗24个月后CCAD较治疗前增加(P<0.05),高密度脂蛋白胆固醇水平较治疗前增高(P<0.05),CIMT、斑块体积及三酰甘油、胆固醇、低密度脂蛋白胆固醇水平均较治疗前降低(P<0.05),观察组各指标改善较对照组明显(P<0.05)。结论阿托伐他汀联合阿司匹林肠溶片可稳定冠心病患者颈动脉易损斑块,控制血脂水平,强化治疗效果优于常规剂量治疗。
作者 何文凤 冯杰 蒲丽君 陈玲 张全波 倪海燕 张敏 李卫东 吕湛
机构地区 川北医学院附属医院心内科 川北医学院附属医院老年病科
出处 《中华实用诊断与治疗杂志》 2013年第10期1007-1009,共3页 Journal of Chinese Practical Diagnosis and Therapy
基金 四川省教育厅重点项目(08zc061)
关键词 冠心病 阿托伐他汀 阿司匹林肠溶片 易损斑块
分类号 R541.4 [医药卫生—心血管疾病]
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共引文献89

同被引文献100

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中华实用诊断与治疗杂志
2013年 第10期

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