摘要
禽流感病毒增殖过程中,必须先找到1个病毒识别并结合的细胞表面分子,借助其"桥梁"作用,才能与宿主细胞结合并进行后续感染,这些细胞表面分子称为受体。病毒与受体的结合如同钥匙与锁一样具有高度特异性。大量的科学试验已经证明禽流感病毒受体主要为唾液酸α2,3半乳糖苷受体(SAα2,3Gal)与唾液酸α2,6半乳糖苷受体(SAα2,6Gal)。本综述就禽流感病毒受体特征及其研究历程进行综述,以加强对禽流感病毒的认识。
Influenza A viruses infection is initiated by a collision between the virus and the cell, a process that arranges the adsorption as the first step. Numerous studies performed have recently revealed that Sialic acid （SA） is a crucial component of influenza A virus receptors. It was observed that human influenza A viruses preferentially recognize NeuSAc a2,6 residues,whereas those of a-vian influenza A viruses bind to a2,3 linkage. This brief review summarizes progress of research on influenza virus receptors.
出处
《中国兽医学报》
CAS
CSCD
北大核心
2013年第10期1615-1622,共8页
Chinese Journal of Veterinary Science
关键词
禽流感病毒
受体
唾液酸
influenza A virus
receptors
sialic acid
