血红素加氧酶-1基因多态性与冠心病发病的关系被引量：1

Relationship between GT repeat polymorphism in heme oxygenase-1 and coronary heart disease

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摘要目的:探讨血红素加氧酶-1(HO-1)基因启动子区域的GT重复序列(GTn)决定的等位基因多态性与冠心病(CHD)发病风险之间的关系。方法:采用聚合酶链式反应(PCR)扩增技术和聚丙烯酰胺凝胶电泳方法分析57例CHD患者和44例健康体检者(健康对照组)HO-1基因启动子区域GTn的分布是否存在差异。结果:与健康对照组比较,CHD组中HO-1基因启动子区S型等位基因(56.8%比38.6%)及SS基因型频率(36.4%比15.8%)显著降低,L型等位基因(43.2%比61.4%)及LL基因型频率(22.7%比38.6%)显著升高(P均<0.05)。结论:血红素加氧酶-1基因启动子区GTn多态性可能增加冠心病的发病风险。 Objective： To explore relationship between alleles polymorphism depended by guanidinium thiocyanate （GT） repeat polymorphism （GTn） in HO-1 gene promoter region and risk of coronary heart disease （CHD）. Methods： Polymerase chain reaction （PCR） and polyacrylamide gel electrophoresis were used to analyze whether there existed difference in distribution of alleles polymorphism depend on GTn in HO- 1 gene promoter region be-tween 57 CHD patients （CHD group） and 44 healthy subjects （healthy control group）. Results： Compared with healthy control group, there were significant decrease in type S allele （56. 8% vs. 38.6%） and genotype frequency of SS （36.4% vs. 15.8%）, and significant increase in type L allele （43.2% vs. 61.4%） and LL （22.7% vs. 38. 6%） in promoter region of HO-1 gene in CHD group, P〈0.05 all. Conclusion： GT repeat polymorphism in pro-moter region of heme oxygenase-1 gene may increase risk of coronary heart disease.

作者陈协辉许云叶媛王东明陈宋明韩蕾许文敏姚公元郝云玲

机构地区深圳市福田区第二人民医院心内科汕头大学医学院第一附属医院

出处《心血管康复医学杂志》 CAS 2013年第5期457-459,共3页 Chinese Journal of Cardiovascular Rehabilitation Medicine

基金深圳市福田区科技计划重点科研资助项目(FTWS201039)

关键词冠状动脉疾病血红素氧化酶基因多态性 Coronary artery disease Heme oxygenase Genes polymorphism

分类号 R541.409 [医药卫生—心血管疾病]

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