摘要
目的探讨粘附分子整合素CD11c在胃癌组织中的表达及其与临床病理特征和预后的关系。方法采用免疫组化染色法检测144例胃癌、10例胃炎和10例胃息肉组织中CD11c的表达水平,并分析影响预后的因素。结果胃癌组织中CD11c的表达水平为(9.9±6.4)个/HPF,明显高于胃炎组织的(5.1±1.8)个/HPF及胃息肉组织的(4.5±2.3)个/HPF。单因素分析显示,CD11c的表达水平与年龄、组织学类型、有无复发无关(P>0.05),与性别、肿瘤部位、肿瘤大小、浸润深度、淋巴结转移、病理分级和TNM分期有关(P<0.05)。CD11c高表达组的中位总生存时间(OS)为67.0个月(95%CI:39.0～112.0个月),低表达组为29.0个月(95%CI:21.0～39.0个月),差异有统计学意义(P<0.05)。Ⅲ、Ⅳ期患者中,CD11c高表达者中位OS较低表达者延长,差异有统计学意义(P<0.05)。Cox多因素分析显示,CD11c高表达组较低表达组死亡风险显著降低(RR=0.52,95%CI:0.29～0.94)。结论 CD11c表达水平与胃癌的预后有关,可以作为胃癌预后的指标。
Objective To investigate the expression of adhesion molecule CD1 lc in gastric cancer tissues and the relevance with patients＇ clinicopathologic features and prognosis. Methods The expression of CD11 c in tissues from 144 gastric cancer patients, 10 gastritis patients and 10 gastric polyp patients was detected by immunohistochemistry. The relationship between CD11c expression and clinicopathologic feature, prognosis of gastric cancer were also analyzed. Results The CD11 c expression in gastric cancer tissues was （9.9 ±6.4）/HPF, significantly higher than （5. 1 ± 1.8）/HPF in gastritis and （4. 5 ±2.3）/HPF in gastric polyps tissues. The CD1 l c expression level in gastric cancer tissues was positively correlated to gender, tumor location, tumor size, depth of invasion, lymph node metastasis, pathological grade and TNM stage, while it was not correlated to age, histological types and recurrence. The median overall survival（OS） of CDI lc highly expressed group and lowly expressed group were 67.0 months （95% CI：39. 0-112. 0 months） and 29. 0 months （95% C1：21.0-39. 0 months） with statistical difference （ P 〈 0. 05 ）. Of gastric cancer patients with stage ]I and IV, the median OS of CD11 c highly expressed group was longer compared with lowly expressed group（ P 〈 0. 05 ）. Cox multiva- riate analysis showed the CDllc highly expressed group significantly reduced the risk of death compared with lowly expressed group （ RR = 0. 52, 95% CI： 0. 29-0. 94）. Conclusion The CD11 c expression level was correlated to the prognosis of gastric cancer, and CD11 c can act as an indicator for prognosis of gastric cancer.
出处
《临床肿瘤学杂志》
CAS
2013年第9期782-785,共4页
Chinese Clinical Oncology
基金
国家自然科学基金资助项目(81171653
30972703)
江苏省自然科学基金资助项目(BK2011246
BK2011247)
常州市社会发展计划基金资助项目(CE20125017
CJ20112020
CS20102020)
常州市科技支撑计划资助项目(CE20125017)
常州市科技基础设施滚动计划资助项目(2010148)
常州市国际科技合作资助项目(CZ20110024)
关键词
胃癌
CD11C
粘附分子
总生存时间
预后
Gastric cancer
CD11c
Adhesion molecule
Overall survival
Prognosis
