摘要
目的探讨足月自然分娩孕妇获得性免疫反应特征。方法将观察对象分为3组,通过流式细胞仪、免疫组化和RTPCR对绒毛膜白细胞进行比较分析。结果 3组在细胞亚型、特异性受体、特异性CAMs和细胞因子各方面差异有统计学意义(P<0.05),不同组别水平不同。结论足月妊娠孕妇CD4+T细胞活化,激活机体趋化因子、细胞因子,使趋化因子受体、细胞黏附分子等,共同参与组成自然分娩的免疫系统。
To explore the immune characteristics and adaptive immune response of choriodecidua leukocyte in human spontaneous parturition at term,we recruited 3 kinds of labors： spontaneous premature delivery（15 cases）,uterine-incision delivery of term pregnancy（17 cases）,and spontaneous delivery of term pregnancy（16 cases）.Chorionic leukocyte in these labors were analyzed by flow cytometry,immunohistochemistry and RT-PCR.Results showed there were statistically different in the density of leukocyte,specific receptor,specific CAMs and cytokines（P 0.05）.In conclusion,CD4＋T cell activation,chemokines activation,cytokines activation,chemokine receptor and cell adhesion molecule expression are all involved in the immune system of human spontaneous labor at term.
出处
《免疫学杂志》
CAS
CSCD
北大核心
2013年第10期915-917,共3页
Immunological Journal
关键词
妊娠
适应性免疫应答
分娩
Pregnancy
Adaptive immune response
Spontaneous labor
