摘要
目的:评价稳心颗粒与小剂量倍他乐克联用治疗高血压合并室性期前收缩的疗效及安全性。方法:将64例高血压合并室性期前收缩的患者随机分为联合用药组(n=32)与单用倍他乐克组(n=32)。观察2组患者治疗4 w后临床症状、24 h动态心电图、不良反应发生情况。结果:2组患者病情有改善,联合用药组临床症状总有效率(90.6%)优于单用倍他乐克组(65.6%),差异有显著性意义(P<0.05);联合用药组24 h动态心电图室性期前收缩数量改善总有效率(87.5%)优于单用倍他乐克组(65.6%),差异有显著性意义(P<0.05);联合用药组的不良反应发生情况少,与单用倍他乐克组比较差异有显著性意义(P<0.05)。结论:稳心颗粒与小剂量倍他乐克联用治疗高血压合并室性期前收缩临床疗效满意且不良反应少,值得临床推广应用。
Objective： Evaluation of Wen-xin granule and small dose Betaloc combined with treatment of hypertension compli- cated with premature ventricular beat （PVB） effect and safety. Methods： 64 patients with hypertension complicated with PVB were randomly divided into a combined treatment group （ n = 32） and single with betaloc group （ rt = 32） . To observe two groups of patients after treatment of 4 weeks of 12-lead ECG and 24h dynamic electrocardiogram. Results： Clinical symptoms improved more frequently in combinde group than in metoprolol group （90. 5%vs 65. 6%, P 〈0. 05） . Effective reduction of PVB on 24h dynamic electrocardio- gram was attained more frequentlyin combined group than in metoprolol group （ 87. 5% vs 65.6% , P 〈 0. 05 ） The combination group the occurrence of adverse reactions, and the single with betaloc groups had significant difference （ P 〈 0. 05 ） . Conclusion： Wen-fin granule and small dose Betaloc in treatment of hypertension complicated with PVB has clinical curative effect and less side effects, it is worthy of clinical application.
出处
《成都中医药大学学报》
2013年第3期81-82,96,共3页
Journal of Chengdu University of Traditional Chinese Medicine
关键词
室性期前收缩
倍他乐克
稳心颗粒
Premature ventricular beat
Betaloc
Wen-xin granule
