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介导重度TRALI的人类中性粒细胞抗原3(HNA-3)在不同种族人群中基因频率分布的研究 被引量：1

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摘要 目的探讨编码人类中性粒细胞抗原-3(Human neutrophil antigens-3,HNA-3)的SLC44A2基因在江苏省汉族人群、美国白种人及美国黑人中的多态性及频率分布。方法采用序列特异性引物聚合酶链反应(Polymerase chain reaction-sequence specific priming,PCR-SSP)方法,分别对随机无亲缘关系的3个种族献血者的SLC44A2基因进行检测,其中包括江苏省的203名汉族、美国的102名白种人和245名黑人;同时采用PCR方法扩增相关外显子及侧翼内含子并进行测序分析,进一步验证PCR-SSP结果的准确性。结果汉族人群中HNA-3a/3a有91例,HNA-3a/3b 86例,HNA-3b/3b 26例;美国白种人中HNA-3a/3a有73例,HNA-3a/3b有26例,HNA-3b/3b有3例;美国黑人中HNA-3a/3a有212例,HNA-3a/3b有31例,HNA-3b/3b有2例。HNA-3a在江苏汉族人群,美国白种人及黑人中的基因频率分别为0.66,0.84和0.93;HNA-3b在江苏汉族人群,美国白种人及黑人中的基因频率分别为0.34,0.16和0.07。HNA-3b/3b纯合子在江苏省汉族人群的频率明显高于美国白种人及美国黑人,具有统计学意义(P<0.01)。结论编码HNA-3抗原的等位基因频率在3种不同种族中的分布存在多态性;该抗原的多态性及可能造成的TRALI需要引起临床上更多的关注。
作者 陈青 肖建宇 黄成垠 孙俊
机构地区 江苏省血液中心
出处 《中国输血杂志》 CAS CSCD 北大核心 2013年第9期856-858,共3页 Chinese Journal of Blood Transfusion
关键词 人类中性粒细胞抗原-3 HNA-3 输血相关的急性肺损伤
分类号 R457.11 [医药卫生—治疗学]
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参考文献16

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共引文献4

同被引文献13

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  • 8李锐,黄宇光.输血相关急性肺损伤的免疫机制[J].中国临床药理学与治疗学,2013,18(5):575-579. 被引量：9
  • 9陈大伟,夏文杰,叶欣,邓晶,丁浩强,李辉,陈扬凯,邵媛,刘静,王嘉励,徐秀章,高国全,付涌水.无偿献血人群中已育女性HLA抗体筛查及特异性分析[J].中国输血杂志,2014,27(3):251-253. 被引量：11
  • 10王同显,马保凤.固有免疫在输血相关急性肺损伤发病机理中的作用[J].中国输血杂志,2014,27(5):546-549. 被引量：6

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中国输血杂志
2013年 第9期

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