摘要
目的探讨不同剂量大蒜素对小鼠胃肠推进运动的影响。方法昆明种小鼠32只,按随机区组设计分为生理盐水组、乙醇组、大剂量大蒜素组(1%,10ml/kg)、小剂量大蒜素组(0.5%,10mL/kg),每组8只。采用小肠亚甲蓝推进实验观察各处理组小鼠胃肠推进运动的变化。结果与生理盐水组相比,乙醇组和大剂量大蒜素组胃肠推进率无明显变化(P〉0.05),而小剂量大蒜素组胃肠推进率明显增加(P〈0.05)。结论小剂量大蒜素(0.5%,10ml/kg)对小鼠胃肠推进运动有显著促进作用。
Objective To investigate the effects of different doses of alilicin on gastrointestinal motility in mice. Methods 32 Kunming mice were randomly divided into 4 groups using randomized block design: saline group, ethylal- cobol group, large dose (1% 10 ml/kg) and small dose (0.5% 10 ml/kg) alilicin groups (n = 8 each). The gastroin- testinal motility in different groups was observed using test of small intestinal propulsion of methylene blue. Results Compared with saline group, no significant changes of gastrointestinal propulsion rate were observed in ethylalcohol group and large dose alilicin group (P 〉 0.05 ) , while the gastrointestinal propulsion rate significantly increased in small dose alilicin group (P 〈 0.05 ). Conclusion Small dose (0.5% 10 ml/kg) alilicin can significantly promote the gastrointestinal motility in mice.
出处
《徐州医学院学报》
CAS
2013年第9期572-573,共2页
Acta Academiae Medicinae Xuzhou
基金
江苏省高等学校大学生创新创业训练计划(201310313015Z)
江苏省高校自然科学研究面上项目(12KJD320005)
徐州医学院“振兴计划”项目