摘要
紧密连接(tight junction,TJ)是上皮细胞之间的一种重要的连接复合体,由跨膜蛋白家族(occludin和claudin)、膜周蛋白家族(ZO蛋白)等构成,起着细胞旁通透屏障和维持细胞极性的作用。多种生理、病理因素参与改变紧密连接结构和功能,如血氧浓度(缺氧)、激素、炎症因子以及雌激素等。紧密连接结构和紧密连接相关因子在正常子宫内膜和胎盘组织中均有表达,与妊娠病理生理的发生发展密切相关。
Tight junction is a fundamental junctional complex of the adjacent epithelial cells,with multiple functions including the barrier effect regulating intercellular permeability and maintaining cellular polarity, which was consisted of several protein families including transmembrane proteins （such as occluding, claudin） and peripheral proteins （such as ZO protein）. The structure and function of tight junction can be changed by many physio-/pathological factors such as anoxia, hormonal, inflammatory factors and estrogen. Tight junction has already been detected in human uterine endometrium and placenta. Factors of tight junction expressed in those tissues and organs. Abnormality of tight junction may be involved in the pregnancy complications.
出处
《国际生殖健康／计划生育杂志》
CAS
2013年第5期384-386,共3页
Journal of International Reproductive Health/Family Planning
基金
国家重点基础研究发展计划(973计划)(2012CB944902
2006CB944005)
关键词
紧密连接部
通透性
细胞极性
缺氧
Tight junctions
Permeability
Cell polarity
Anoxia
